Functional Characterization of Reduced Folate Carrier and Protein-Coupled Folate Transporter for Antifolates Accumulation in Non-Small Cell Lung Cancer Cells.
第一作者:
Yuqing,Wang
第一单位:
Translational Medicine Research Center, Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province, Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, Hangzhou, China (Y.W., J.L., M.B., Z.M., S.M., S.Z.); Laboratory of Pharmaceutical Analysis and Drug Metabolism, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China (J.L., H.J.); The Fourth College of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, China (Y.X.); and Shanghai AB SCIEX Analytical Instrument Trading Co., Ltd., Shanghai, China (D.L.).
作者:
主题词
人类(Humans);癌, 非小细胞肺(Carcinoma, Non-Small-Cell Lung);叶酸拮抗剂(Folic Acid Antagonists);肺肿瘤(Lung Neoplasms);还原叶酸载体蛋白(Reduced Folate Carrier Protein);质子偶联叶酸盐转运蛋白(Proton-Coupled Folate Transporter);动物(Animals);氢离子浓度(Hydrogen-Ion Concentration);细胞系, 肿瘤(Cell Line, Tumor);叶酸(Folic Acid);小鼠(Mice);甲氨蝶呤(Methotrexate);生物转运(Biological Transport);小鼠, 裸(Mice, Nude);女(雌)性(Female)
DOI
10.1124/dmd.124.001872
PMID
39261014
发布时间
2025-02-12
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Drug metabolism and disposition
1332-1344页
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