The Polycomb system sustains promoters in a deep OFF state by limiting pre-initiation complex formation to counteract transcription.

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第一作者： Aleksander T,Szczurek

第一单位： Department of Biochemistry, University of Oxford, Oxford, UK. aleksander.szczurek@bioch.ox.ac.uk.

作者： Aleksander T,Szczurek ^[1] ; Emilia,Dimitrova ^[2] ; Jessica R,Kelley ^[2] ; Neil P,Blackledge ^[2] ; Robert J,Klose ^[3]

作者单位： Department of Biochemistry, University of Oxford, Oxford, UK. aleksander.szczurek@bioch.ox.ac.uk. ^[1] Department of Biochemistry, University of Oxford, Oxford, UK. ^[2] Department of Biochemistry, University of Oxford, Oxford, UK. rob.klose@bioch.ox.ac.uk. ^[3]

主题词启动区, 遗传(Promoter Regions, Genetic);人类(Humans);动物(Animals);转录, 遗传(Transcription, Genetic);小鼠(Mice);基因表达调控(Gene Expression Regulation)

DOI 10.1038/s41556-024-01493-w

PMID 39261718

发布时间 2024-10-25

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