Hydrophobic interaction chromatography in continuous flow-through mode for product-related variant removal.

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第一作者： Yiran,Wang

第一单位： Biologics Development, Bristol Myers Squibb, 38 Jackson Road, Devens, MA, USA. Electronic address: yiran.wang@bms.com.

作者： Yiran,Wang ^[1] ; Ujjwal,Bhaskar ^[2] ; Naresh,Chennamsetty ^[2] ; Steven,Noyes ^[2] ; Jing,Guo ^[2] ; Yuanli,Song ^[3] ; Angela,Lewandowski ^[2] ; Sanchayita,Ghose ^[2]

作者单位： Biologics Development, Bristol Myers Squibb, 38 Jackson Road, Devens, MA, USA. Electronic address: yiran.wang@bms.com. ^[1] Biologics Development, Bristol Myers Squibb, 38 Jackson Road, Devens, MA, USA. ^[2] Genomic Medicine Unit CMC Purification Process Development, Sanofi, Waltham, MA, USA. ^[3]

关键词 Antibody Frontal analysis Hydrophobic interaction chromatography Multicolumn continuous chromatography Product-related variant separation

主题词亲水和疏水相互作用(Hydrophobic and Hydrophilic Interactions);抗体, 单克隆(Antibodies, Monoclonal);色谱法, 液相(Chromatography, Liquid);仓鼠属(Cricetulus);CHO细胞(CHO Cells);动物(Animals);药物污染(Drug Contamination)

DOI 10.1016/j.chroma.2024.465356

PMID 39276416

发布时间 2024-10-21

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