Predictive power of deleterious single amino acid changes to infer on AAV2 and AAV2-13 capsids fitness.

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第一作者： Tiziana,La Bella

第一单位： Genethon, 91000 Evry, France.;Université Paris-Saclay, University Evry, Inserm, Genethon, Integrare Research Unit UMR_S951, 91000 Evry, France.

作者： Tiziana,La Bella ^[1] ; Bérangère,Bertin ^[1] ; Ante,Mihaljevic ^[1] ; Justine,Nozi ^[1] ; Patrice,Vidal ^[1] ; Sandrine,Imbeaud ^[2] ; Jean-Charles,Nault ^[3] ; Jessica,Zucman-Rossi ^[4] ; Giuseppe,Ronzitti ^[1]

作者单位： Genethon, 91000 Evry, France.;Université Paris-Saclay, University Evry, Inserm, Genethon, Integrare Research Unit UMR_S951, 91000 Evry, France. ^[1] Centre de Recherche des Cordeliers, Sorbonne Université, Université de Paris, INSERM, 75000 Paris, France. ^[2] Centre de Recherche des Cordeliers, Sorbonne Université, Université de Paris, INSERM, 75000 Paris, France.;Avicenne Hospital, Paris-Seine-Saint-Denis University Hospital, APHP, 93000 Bobigny, France. ^[3] Centre de Recherche des Cordeliers, Sorbonne Université, Université de Paris, INSERM, 75000 Paris, France.;Hôpital Européen Georges Pompidou, AP-HP, 75000 Paris, France. ^[4]

关键词 AAV vector AAV viability adeno-associated virus capsid engineering deleterious mutation fitness hyper variable regions prediction model wild-type variant

DOI 10.1016/j.omtm.2024.101327

PMID 39286333

发布时间 2024-09-18

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Molecular therapy. Methods & clinical development

2024年32卷3期

101327页

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Predictive power of deleterious single amino acid changes to infer on AAV2 and AAV2-13 capsids fitness.

Molecular therapy. Methods & clinical development

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Molecular therapy. Methods & clinical development

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Predictive power of deleterious single amino acid changes to infer on AAV2 and AAV2-13 capsids fitness.

Molecular therapy. Methods & clinical development

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Molecular therapy. Methods & clinical development

相关期刊

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