Functional and dynamic profiling of transcript isoforms reveals essential roles of alternative splicing in interferon response.

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作者： Mahoko Takahashi,Ueda ^[1] ; Jun,Inamo ^[2] ; Fuyuki,Miya ^[3] ; Mihoko,Shimada ^[4] ; Kensuke,Yamaguchi ^[5] ; Yuta,Kochi ^[6]

作者单位： Department of Genomic Function and Diversity, Medical Research Institute, Tokyo Medical and Dental University, Tokyo 113-8510, Japan. ^[1] Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, USA; Department of Biomedical Informatics, Center for Health Artificial Intelligence, University of Colorado School of Medicine, Aurora, CO, USA. ^[2] Center for Medical Genetics, Keio University School of Medicine, Tokyo 160-8582, Japan. ^[3] National Center for Global Health and Medicine, Tokyo 162-8655, Japan. ^[4] Biomedical Engineering Research Innovation Center, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Tokyo 113-8510, Japan; Laboratory for Autoimmune Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa 230-0045, Japan; Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. ^[5] Department of Genomic Function and Diversity, Medical Research Institute, Tokyo Medical and Dental University, Tokyo 113-8510, Japan; Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. Electronic address: y-kochi.gfd@mri.tmd.ac.jp. ^[6]

关键词 ISGs PacBio Sequel II/IIe alternative splicing regulation interferon-stimulated genes intron retention isoform switching long-read RNA-seq

主题词选择性剪接(Alternative Splicing);人类(Humans);蛋白质亚型(Protein Isoforms);免疫, 先天(Immunity, Innate);干扰素Ⅰ型(Interferon Type I);B-淋巴细胞(B-Lymphocytes);基因表达谱(Gene Expression Profiling)

DOI 10.1016/j.xgen.2024.100654

PMID 39288763

发布时间 2024-11-30

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Cell genomics

2024年4卷10期

100654页

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Functional and dynamic profiling of transcript isoforms reveals essential roles of alternative splicing in interferon response.

Cell genomics

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Functional and dynamic profiling of transcript isoforms reveals essential roles of alternative splicing in interferon response.

Cell genomics

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Cell genomics

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