Utilizing a hydrophobic primary container surface to reduce the formation of subvisible particles in monoclonal antibody solution caused by fluid shear.

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第一作者： Xinyue,Wang

第一单位： School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Liaoning 110016, China.

作者： Xinyue,Wang ^[1] ; Junjie,Wang ^[1] ; Yang,Han ^[2] ; Xingchun,Jiang ^[1] ; Sixian,Cao ^[1] ; Dongze,Xu ^[1] ; Tiancheng,Xiong ^[1] ; Xiang,Guo ^[1] ; Cui,Wang ^[1] ; Sha,Guo ^[3] ; Hongying,Song ^[4] ; Ting,Dong ^[4] ; Le,Zhang ^[4] ; Zhenming,An ^[4] ; Jun,Liu ^[4] ; Jing,Han ^[5] ; Hao,Wu ^[6]

作者单位： School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Liaoning 110016, China. ^[1] School of Traditional Chinese Medicine, Shenyang Pharmaceutical University, Liaoning 110016, China. ^[2] National Institutes for Food and Drug Control, NHC Key Laboratory of Research on Quality and Standardization of Biotech Products, NMPA Key Laboratory for Quality Research and Evaluation of Biological Products, Beijing 102629, China. ^[3] Qilu Pharmaceutical, Shandong 250104, China. ^[4] School of Functional Food and Wine, Shenyang Pharmaceutical University, Liaoning 110016, China. Electronic address: hj-8080@163.com. ^[5] School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Liaoning 110016, China. Electronic address: haowu@syphu.edu.cn. ^[6]

关键词 Human complement Interfaces Monoclonal antibody Primary container Protein aggregation Subvisible particle