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Elucidating ferroptosis mechanisms in heart failure through transcriptomics, single-cell sequencing, and experimental validation.

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第一作者： Kaiyuan,Li

第一单位： Graduate School of Dalian Medical University, Dalian Medical University, Dalian, Liaoning 116000, PR China; Department of Cardiology, The Affiliated Taizhou People's Hospital of Nanjing Medical University, Taizhou, Jiangsu 225300, PR China.

作者： Kaiyuan,Li ^[1] ; Peng,Liu ^[2] ; Lingyu,Han ^[3] ; Jing,Tian ^[4] ; Zhipeng,Zheng ^[1] ; Min,Sha ^[3] ; Jun,Ye ^[5] ; Li,Zhu ^[6]

作者单位： Graduate School of Dalian Medical University, Dalian Medical University, Dalian, Liaoning 116000, PR China; Department of Cardiology, The Affiliated Taizhou People's Hospital of Nanjing Medical University, Taizhou, Jiangsu 225300, PR China. ^[1] Department of Cardiology, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330000, PR China. ^[2] Department of Cardiology, The Affiliated Taizhou People's Hospital of Nanjing Medical University, Taizhou, Jiangsu 225300, PR China. ^[3] Department of Cardiology, Central Hospital Affiliated to Shandong First Medical University, Jinan, Shandong 250000, PR China. ^[4] Graduate School of Dalian Medical University, Dalian Medical University, Dalian, Liaoning 116000, PR China; Department of Cardiology, The Affiliated Taizhou People's Hospital of Nanjing Medical University, Taizhou, Jiangsu 225300, PR China. Electronic address: dingyinglinyejun@126.com. ^[5] Graduate School of Dalian Medical University, Dalian Medical University, Dalian, Liaoning 116000, PR China; Department of Cardiology, The Affiliated Taizhou People's Hospital of Nanjing Medical University, Taizhou, Jiangsu 225300, PR China. Electronic address: tzheartchina@126.com. ^[6]

关键词 Ferroptosis Heart failure QSOX1 SLC39A14 Single-cell sequencing Transcriptomics

医学主题词心力衰竭(Heart Failure);动物(Animals);小鼠(Mice);单细胞分析(Single-Cell Analysis);人类(Humans);小鼠, 近交C57BL(Mice, Inbred C57BL);基因表达谱(Gene Expression Profiling)

DOI 10.1016/j.cellsig.2024.111416

PMID 39293745

发布时间 2025-07-24

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