换一批
换一批Irinotecan hydrochloride liposome HR070803 in combination with 5-fluorouracil and leucovorin in locally advanced or metastatic pancreatic ductal adenocarcinoma following prior gemcitabine-based therapy (PAN-HEROIC-1): a phase 3 trial.
作者：
Jiujie,Cui [1]
;
Shukui,Qin [2]
;
Yuhong,Zhou [3]
;
Shuang,Zhang [4]
;
Xiaofeng,Sun [5]
;
Mingjun,Zhang [6]
;
Jiuwei,Cui [7]
;
Weijia,Fang [8]
;
Kangsheng,Gu [9]
;
Zhihua,Li [10]
;
Jufeng,Wang [11]
;
Xiaobing,Chen [11]
;
Jun,Yao [12]
;
Jun,Zhou [13]
;
Gang,Wang [14]
;
Yuxian,Bai [15]
;
Juxiang,Xiao [16]
;
Wensheng,Qiu [17]
;
Bangmao,Wang [18]
;
Tao,Xia [19]
;
Chunyue,Wang [20]
;
Li,Kong [21]
;
Jiajun,Yin [22]
;
Tao,Zhang [23]
;
Xionghu,Shen [24]
;
Deliang,Fu [25]
;
Chuntao,Gao [26]
;
Huan,Wang [27]
;
Quanren,Wang [27]
;
Liwei,Wang [28]
作者单位：
Oncology Department and State Key Laboratory of Systems Medicine for Cancer of Shanghai Cancer Institute, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.
[1]
GI Cancer Center, Nanjing Tianyinshan Hospital, China Pharmaceutical University, Nanjing, China. qinsk@csco.org.cn.
[2]
Medical Oncology, Zhongshan Hospital Affiliated with Fudan University, Shanghai, China.
[3]
Department of Biotherapy, West China School of Medicine/West China Hospital of Sichuan University, Chengdu, China.
[4]
Internal Medicine, Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research & The Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, China.
[5]
Medical Oncology, The Second Affiliated Hospital of Anhui Medical University, Hefei, China.
[6]
Department of Oncology, The First Hospital of Jilin University, Changchun, China.
[7]
Medical Oncology III, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
[8]
Medical Oncology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
[9]
Department of Oncology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.
[10]
Department of Oncology, The Affiliated Cancer Hospital, Zhengzhou University, Zhengzhou, China.
[11]
Department of Oncology, The First Affiliated Hospital of Henan University of Science and Technology, Luoyang, China.
[12]
Department of Gastrointestinal Oncology, Peking University Cancer Hospital & Institute, Beijing, China.
[13]
Department of Oncology, The First Affiliated Hospital of USTC Anhui Provincial Hospital, Hefei, China.
[14]
Department of Oncology, Harbin Medical University Cancer Hospital, Harbin, China.
[15]
Medical Oncology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
[16]
Department of Oncology, The Affiliated Hospital of Qingdao University, Qingdao, China.
[17]
Department of Gastroenterology, Tianjin Medical University General Hospital, Tianjin, China.
[18]
Division of Gastrointestinal and Pancreatic Surgery, Zhejiang Provincial People's Hospital, Hangzhou, China.
[19]
Medical Oncology, The First Affiliated Hospital of Xiamen University, Xiamen, China.
[20]
Department of Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China.
[21]
General Surgery, Affiliated Zhongshan Hospital of Dalian University, Dalian, China.
[22]
Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
[23]
Department of Oncology, Affiliated Hospital of Yanbian University, Yanji, China.
[24]
Pancreatic Surgery, Huashan Hospital, Fudan University, Shanghai, China.
[25]
Pancreatic Surgery, Tianjin Medical University Cancer Institute & Hospital, Tianjin, China.
[26]
Jiangsu Hengrui Pharmaceuticals Co., Ltd, Shanghai, China.
[27]
Oncology Department and State Key Laboratory of Systems Medicine for Cancer of Shanghai Cancer Institute, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China. liweiwang@shsmu.edu.cn.
[28]
主题词
人类(Humans);氟尿嘧啶(Fluorouracil);女(雌)性(Female);男(雄)性(Male);醛氢叶酸(Leucovorin);癌, 胰腺管(Carcinoma, Pancreatic Ductal);中年人(Middle Aged);老年人(Aged);抗肿瘤联合化疗方案(Antineoplastic Combined Chemotherapy Protocols);脱氧胞苷(Deoxycytidine);胰腺肿瘤(Pancreatic Neoplasms);脂质体(Liposomes);成年人(Adult);双盲法(Double-Blind Method);肿瘤转移(Neoplasm Metastasis)
DOI
10.1038/s41392-024-01948-4
PMID
39300077
发布时间
2025-01-23
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Signal transduction and targeted therapy
Signal transduction and targeted therapy
2024年9卷1期
248页
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