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首页> Neurobiology of disease> Alpha-synuclein modulates the repair of genomic DNA double-strand breaks in a DNA-PK<sub>cs</sub>-regulated manner.

Alpha-synuclein modulates the repair of genomic DNA double-strand breaks in a DNA-PK<sub>cs</sub>-regulated manner.

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作者： Elizabeth P,Rose ^[1] ; Valerie R,Osterberg ^[2] ; Vera,Gorbunova ^[3] ; Vivek K,Unni ^[4]

作者单位： Jungers Center for Neurosciences Research, Oregon Health & Science University, Portland, OR 97239, United States of America; Neuroscience Graduate Program, Vollum Institute, Oregon Health & Science University, Portland, OR 97239, United States of America. ^[1] Jungers Center for Neurosciences Research, Oregon Health & Science University, Portland, OR 97239, United States of America. ^[2] Departments of Biology and Medicine, University of Rochester, Rochester, NY 14620, United States of America. ^[3] Jungers Center for Neurosciences Research, Oregon Health & Science University, Portland, OR 97239, United States of America; OHSU Parkinson Center, Department of Neurology, Oregon Health & Science University, Portland, OR 97239, United States of America. Electronic address: unni@ohsu.edu. ^[4]

关键词 DNA double-strand break repair DNA-PK(cs)Lewy body disease Parkinson's disease α-Synuclein

主题词 DNA断裂, 双链(DNA Breaks, Double-Stranded);α突触核蛋白(alpha-Synuclein);动物(Animals);DNA活化蛋白激酶(DNA-Activated Protein Kinase);小鼠(Mice);人类(Humans);神经元(Neurons);DNA修复(DNA Repair);DNA结合蛋白质类(DNA-Binding Proteins)

DOI 10.1016/j.nbd.2024.106675

PMID 39306014

发布时间 2024-11-14

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