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A novel mouse model reproducing frontal alterations related to the prodromal stage of dementia with LEWY bodies.

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第一作者： Estelle,Schueller

第一单位： Université de Strasbourg, Laboratoire de Neurosciences Cognitives et Adaptatives (LNCA), UMR7364 CNRS, 12 Rue Goethe, Strasbourg, France.

作者： Estelle,Schueller ^[1] ; Iris,Grgurina ^[1] ; Brigitte,Cosquer ^[1] ; Elodie,Panzer ^[1] ; Noémie,Penaud ^[1] ; Anne,Pereira de Vasconcelos ^[1] ; Aline,Stéphan ^[1] ; Karine,Merienne ^[1] ; Jean-Christophe,Cassel ^[1] ; Chantal,Mathis ^[1] ; Frédéric,Blanc ^[2] ; Olivier,Bousiges ^[3] ; Anne-Laurence,Boutillier ^[4]

作者单位： Université de Strasbourg, Laboratoire de Neurosciences Cognitives et Adaptatives (LNCA), UMR7364 CNRS, 12 Rue Goethe, Strasbourg, France. ^[1] ICube Laboratory UMR 7357 and FMTS (Fédération de Médecine Translationnelle de Strasbourg), IMIS team, University of Strasbourg and CNRS, Strasbourg, France; CM2R (Research and Resources Memory Center), Geriatric Day Hospital, Neurogeriatric Service, Geriatrics Department, University Hospital of Strasbourg, Strasbourg, France. ^[2] Université de Strasbourg, Laboratoire de Neurosciences Cognitives et Adaptatives (LNCA), UMR7364 CNRS, 12 Rue Goethe, Strasbourg, France; ICube Laboratory UMR 7357 and FMTS (Fédération de Médecine Translationnelle de Strasbourg), IMIS team, University of Strasbourg and CNRS, Strasbourg, France; University Hospital of Strasbourg, Laboratory of Biochemistry and Molecular Biology, Avenue Molière, Hôpital de Hautepierre, Strasbourg, France. Electronic address: bousiges@unistra.fr. ^[3] Université de Strasbourg, Laboratoire de Neurosciences Cognitives et Adaptatives (LNCA), UMR7364 CNRS, 12 Rue Goethe, Strasbourg, France. Electronic address: laurette@unistra.fr. ^[4]

关键词 Dementia with Lewy bodies Frontal cortex Human cohort Prodromal stage Transgenic mouse model α-Synuclein