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Effect of antiemetics on zolbetuximab-induced gastric injury and emesis in ferrets.

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第一作者： Fumitaka,Kinugasa

第一单位： Research Program Management - Applied Research Management, Applied Research & Operations, Astellas Pharma, Inc., Tsukuba, Ibaraki, Japan. Electronic address: fumitaka.kinugasa@astellas.com.

作者： Fumitaka,Kinugasa ^[1] ; Satoru,Kajikawa ^[2] ; Jane,Weng ^[3] ; Tohru,Ugawa ^[4] ; Hiroshi,Fushiki ^[3] ; Yosuke,Yamanaka ^[5] ; Masanori,Nagata ^[6] ; Gillian,Haggerty ^[7] ; Shinobu,Akuzawa ^[8] ; Taisuke,Nakazawa ^[9] ; Hiroshi,Suzuki ^[10] ; Taiji,Sawamoto ^[11]

作者单位： Research Program Management - Applied Research Management, Applied Research & Operations, Astellas Pharma, Inc., Tsukuba, Ibaraki, Japan. Electronic address: fumitaka.kinugasa@astellas.com. ^[1] Applied Safety - Non-clinical Regulatory Science, Applied Research & Operations, Astellas Pharma, Inc., Tsukuba, Ibaraki, Japan. ^[2] Research Program Management - Applied Research Management, Applied Research & Operations, Astellas Pharma, Inc., Tsukuba, Ibaraki, Japan. ^[3] Regulatory Management - Non-clinical Regulatory Science, Applied Research & Operations, Astellas Pharma, Inc., Tsukuba, Ibaraki, Japan. ^[4] Applied Drug Metabolism & Pharmacokinetics - Non-clinical Regulatory Science, Applied Research & Operations, Astellas Pharma, Inc., Tsukuba, Ibaraki, Japan. ^[5] Biomarker Discovery & Development - Non-clinical Biomedical Science, Applied Research & Operations, Astellas Pharma, Inc., Tsukuba, Ibaraki, Japan. ^[6] Translational Science & Development Toxicology - Applied Safety, Astellas Pharma US, Inc., Northbrook, IL, USA. ^[7] Applied Pharmacology - Non-clinical Regulatory Science, Applied Research & Operations, Astellas Pharma, Inc., Tsukuba, Ibaraki, Japan. ^[8] Immuno-Oncology, Astellas Pharma, Inc., Tsukuba, Ibaraki, Japan. ^[9] Applied Research Management, Applied Research & Operations, Astellas Pharma, Inc., Tsukuba, Ibaraki, Japan. ^[10] Applied Research & Operations, Astellas Pharma, Inc., Tsukuba, Ibaraki, Japan. ^[11]

关键词 Adenocarcinoma / pathology Antibodies, Monoclonal / adverse effects Antibodies, Monoclonal, Humanized / adverse effects Claudins / therapeutic use Esophagogastric junction / pathology