Chem-CRISPR/dCas9FCPF: a platform for chemically induced epigenome editing.

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作者： Mukaddes,Altinbay ^[1] ; Jianhui,Wang ^[1] ; Jie,Chen ^[2] ; Daniel,Schäfer ^[1] ; Maximilian,Sprang ^[3] ; Biljana,Blagojevic ^[4] ; Stefan,Wölfl ^[4] ; Miguel A,Andrade-Navarro ^[3] ; Ivan,Dikic ^[5] ; Stefan,Knapp ^[6] ; Xinlai,Cheng ^[2]

作者单位： Buchmann Institute for Molecular Life Sciences, Goethe University Frankfurt am Main, Max-von-Laue-Straße 15, 60438 Frankfurt am Main, Germany.;Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Max-von-Laue-Straße 9, 60438 Frankfurt am Main, Germany. ^[1] Buchmann Institute for Molecular Life Sciences, Goethe University Frankfurt am Main, Max-von-Laue-Straße 15, 60438 Frankfurt am Main, Germany.;Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Max-von-Laue-Straße 9, 60438 Frankfurt am Main, Germany.;Frankfurt Cancer Institute, Paul-Ehrlich-Straße 42-44, 60596 Frankfurt am Main, Germany.;University Cancer Center (UCT) Frankfurt, Theodor-Stern-Kai7, 60590, Frankfurt am Main, Germany. ^[2] Faculty of Biology, Johannes Gutenberg University Mainz, Gresemundweg 2, 55128 Mainz, Germany. ^[3] Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, Im Neuenheimer Feld 364, Heidelberg, Germany. ^[4] Institute of Biochemistry II, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Germany. ^[5] Buchmann Institute for Molecular Life Sciences, Goethe University Frankfurt am Main, Max-von-Laue-Straße 15, 60438 Frankfurt am Main, Germany.;Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Max-von-Laue-Straße 9, 60438 Frankfurt am Main, Germany.;Frankfurt Cancer Institute, Paul-Ehrlich-Straße 42-44, 60596 Frankfurt am Main, Germany.;DKTK translational cancer network, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Germany. ^[6]