An AI-informed NMR structure reveals an extraordinary LETM1 F-EF-hand domain that functions as a two-way regulator of mitochondrial calcium.
第一作者:
Qi-Tong,Lin
第一单位:
Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON N6A5C1, Canada.
作者:
医学主题词
钙(Calcium);人类(Humans);线粒体(Mitochondria);模型, 分子(Models, Molecular);EF基序(EF Hand Motifs);核磁共振, 生物分子(Nuclear Magnetic Resonance, Biomolecular);膜蛋白质类(Membrane Proteins);蛋白质结合(Protein Binding);结合部位(Binding Sites);亲水和疏水相互作用(Hydrophobic and Hydrophilic Interactions);氢离子浓度(Hydrogen-Ion Concentration);氨基酸序列(Amino Acid Sequence);钙结合蛋白质类(Calcium-Binding Proteins)
DOI
10.1016/j.str.2024.08.020
PMID
39317198
发布时间
2024-11-09
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Structure (London, England
2063-2082.e5页
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