Sialic acid and PirB are not required for targeting of neural circuits by neurotropic mammalian orthoreovirus.

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作者： Kira A,Griswold ^[1] ; Iaroslavna,Vasylieva ^[2] ; Megan C,Smith ^[2] ; Kay L,Fiske ^[3] ; Olivia L,Welsh ^[3] ; Alexa N,Roth ^[3] ; Alan M,Watson ^[2] ; Simon C,Watkins ^[2] ; Danica M,Sutherland ^[3] ; Terence S,Dermody ^[4]

作者单位： Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.;Institute of Infection, Inflammation, and Immunity, UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA. ^[1] Department of Cell Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.;Center for Biologic Imaging, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. ^[2] Institute of Infection, Inflammation, and Immunity, UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA.;Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA. ^[3] Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.;Institute of Infection, Inflammation, and Immunity, UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA.;Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA. ^[4]

关键词 CLARITY MiPACT-HCR PirB neuropathogenesis neurotropic viruses reovirus sialic acid

主题词动物(Animals);女(雌)性(Female);小鼠(Mice);动物, 新生(Animals, Newborn);脑(Brain);哺乳动物正呼肠孤病毒3(Mammalian orthoreovirus 3);小鼠, 近交C57BL(Mice, Inbred C57BL);N-乙酰神经氨酸(N-Acetylneuraminic Acid);神经元(Neurons);正呼肠病毒, 哺乳动物(Orthoreovirus, Mammalian);受体, 免疫(Receptors, Immunologic);受体, 病毒(Receptors, Virus);呼肠病毒科感染(Reoviridae Infections);病毒嗜亲性(Viral Tropism);男(雄)性(Male)

DOI 10.1128/msphere.00629-24

PMID 39320067

发布时间 2024-11-13

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Sialic acid and PirB are not required for targeting of neural circuits by neurotropic mammalian orthoreovirus.

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Sialic acid and PirB are not required for targeting of neural circuits by neurotropic mammalian orthoreovirus.

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