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Designed endocytosis-inducing proteins degrade targets and amplify signals.

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第一作者: Buwei,Huang
第一单位: Department of Biochemistry, University of Washington, Seattle, WA, USA.;Institute for Protein Design, University of Washington, Seattle, WA, USA.;Department of Bioengineering, University of Washington, Seattle, WA, USA.
作者单位: Department of Biochemistry, University of Washington, Seattle, WA, USA.;Institute for Protein Design, University of Washington, Seattle, WA, USA.;Department of Bioengineering, University of Washington, Seattle, WA, USA. [1] Department of Biochemistry, University of Washington, Seattle, WA, USA.;Institute for Protein Design, University of Washington, Seattle, WA, USA. [2] Department of Chemistry, Stanford University, Stanford, CA, USA. [3] Department of Biochemistry, University of Washington, Seattle, WA, USA.;Institute for Protein Design, University of Washington, Seattle, WA, USA.;Howard Hughes Medical Institute, University of Washington, Seattle, WA, USA. [4] Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal. [5] Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX, USA. [6] Institute for Protein Design, University of Washington, Seattle, WA, USA. [7] Novo Nordisk, Måløv, Denmark. [8] Departments of Biomedical Engineering and Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, USA.;Medical Scientist Training Program, Johns Hopkins University School of Medicine, Baltimore, MD, USA. [9] Department of Microbiology and Immunology, University of California San Francisco, San Francisco, CA, USA. [10] Hubrecht Institute, Utrecht, The Netherlands. [11] Harvard Medical School, Harvard University, Boston, MA, USA. [12] Division of Biology and Bioengineering, California Institute of Technology, Pasadena, CA, USA. [13] School of Life Sciences, Westlake University, Hangzhou, China. [14] Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal.;Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, UK. [15] Department of Chemistry, Stanford University, Stanford, CA, USA.;Howard Hughes Medical Institute, Stanford, CA, USA.;Sarafan ChEM-H, Stanford University, Stanford, CA, USA. [16] Department of Biochemistry, University of Washington, Seattle, WA, USA. dabaker@uw.edu.;Institute for Protein Design, University of Washington, Seattle, WA, USA. dabaker@uw.edu.;Howard Hughes Medical Institute, University of Washington, Seattle, WA, USA. dabaker@uw.edu. [17]
DOI 10.1038/s41586-024-07948-2
PMID 39322662
发布时间 2026-04-21
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