Direct asymmetric synthesis of β-branched aromatic α-amino acids using engineered phenylalanine ammonia lyases.

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作者： Chenghai,Sun ^[1] ; Gen,Lu ^[2] ; Baoming,Chen ^[2] ; Guangjun,Li ^[2] ; Ya,Wu ^[2] ; Yannik,Brack ^[3] ; Dong,Yi ^[4] ; Yu-Fei,Ao ^[3] ; Shuke,Wu ^[5] ; Ren,Wei ^[3] ; Yuhui,Sun ^[2] ; Guifa,Zhai ^[6] ; Uwe T,Bornscheuer ^[7]

作者单位： Department of Biotechnology and Enzyme Catalysis, Institute of Biochemistry, University of Greifswald, Greifswald, Germany. chenghai.sun23@outlook.com. ^[1] School of Pharmacy, Tongji Medical College of Huazhong University of Science and Technology, Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Wuhan, China. ^[2] Department of Biotechnology and Enzyme Catalysis, Institute of Biochemistry, University of Greifswald, Greifswald, Germany. ^[3] Research Center for Systems Biosynthesis, China State Institute of Pharmaceutical Industry, National Key Laboratory of Lead Druggability Research, Shanghai, China. ^[4] College of Life Science and Technology, Huazhong Agriculture University, Wuhan, China. ^[5] School of Pharmacy, Tongji Medical College of Huazhong University of Science and Technology, Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Wuhan, China. gfzhai@hust.edu.cn. ^[6] Department of Biotechnology and Enzyme Catalysis, Institute of Biochemistry, University of Greifswald, Greifswald, Germany. uwe.bornscheuer@uni-greifswald.de. ^[7]