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A living organoid biobank of patients with Crohn's disease reveals molecular subtypes for personalized therapeutics.

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第一作者： Courtney,Tindle

第一单位： Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA; HUMANOID™ Center of Research Excellence (CoRE), University of California, San Diego, La Jolla, CA 92093, USA.

作者： Courtney,Tindle ^[1] ; Ayden G,Fonseca ^[1] ; Sahar,Taheri ^[2] ; Gajanan D,Katkar ^[3] ; Jasper,Lee ^[4] ; Priti,Maity ^[1] ; Ibrahim M,Sayed ^[4] ; Stella-Rita,Ibeawuchi ^[4] ; Eleadah,Vidales ^[1] ; Rama F,Pranadinata ^[1] ; Mackenzie,Fuller ^[1] ; Dominik L,Stec ^[1] ; Mahitha Shree,Anandachar ^[4] ; Kevin,Perry ^[1] ; Helen N,Le ^[5] ; Jason,Ear ^[3] ; Brigid S,Boland ^[6] ; William J,Sandborn ^[7] ; Debashis,Sahoo ^[8] ; Soumita,Das ^[9] ; Pradipta,Ghosh ^[10]

作者单位： Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA; HUMANOID™ Center of Research Excellence (CoRE), University of California, San Diego, La Jolla, CA 92093, USA. ^[1] Department of Computer Science and Engineering, Jacobs School of Engineering, University of California, San Diego, La Jolla, CA 92093, USA. ^[2] Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA. ^[3] Department of Pathology, University of California, San Diego, La Jolla, CA 92093, USA. ^[4] Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA. ^[5] Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address: bboland@health.ucsd.edu. ^[6] Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address: wsandborn@health.ucsd.edu. ^[7] Department of Computer Science and Engineering, Jacobs School of Engineering, University of California, San Diego, La Jolla, CA 92093, USA; Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address: dsahoo@ucsd.edu. ^[8] HUMANOID™ Center of Research Excellence (CoRE), University of California, San Diego, La Jolla, CA 92093, USA; Department of Pathology, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address: soumita_das@uml.edu. ^[9] Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA; HUMANOID™ Center of Research Excellence (CoRE), University of California, San Diego, La Jolla, CA 92093, USA; Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address: prghosh@ucsd.edu. ^[10]

关键词 barrier integrity host-microbe interaction inflammatory bowel disease patient-derived organoids therapeutics

医学主题词人类(Humans);Crohn病(Crohn Disease);类器官(Organoids);生物标本库(Biological Specimen Banks);成年人(Adult);男(雄)性(Male);女(雌)性(Female);表型(Phenotype);结肠(Colon);中年人(Middle Aged);成体干细胞(Adult Stem Cells)

DOI 10.1016/j.xcrm.2024.101748

PMID 39332415

发布时间 2026-02-17

基金项目

P30 DK120515/DK/NIDDK NIH HHS/United States

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2024年5卷10期

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A living organoid biobank of patients with Crohn's disease reveals molecular subtypes for personalized therapeutics.

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A living organoid biobank of patients with Crohn's disease reveals molecular subtypes for personalized therapeutics.

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