换一批Blood-based DNA methylation and exposure risk scores predict PTSD with high accuracy in military and civilian cohorts.
第一作者：
Agaz H,Wani
第一单位：
Genomics Program, College of Public Health, University of South Florida, Tampa, FL, USA.
作者：
Agaz H,Wani [1]
;
Seyma,Katrinli [2]
;
Xiang,Zhao [3]
;
Nikolaos P,Daskalakis [4]
;
Anthony S,Zannas [5]
;
Allison E,Aiello [6]
;
Dewleen G,Baker [7]
;
Marco P,Boks [8]
;
Leslie A,Brick [9]
;
Chia-Yen,Chen [10]
;
Shareefa,Dalvie [11]
;
Catherine,Fortier [12]
;
Elbert,Geuze [13]
;
Jasmeet P,Hayes [14]
;
Ronald C,Kessler [15]
;
Anthony P,King [16]
;
Nastassja,Koen [17]
;
Israel,Liberzon [18]
;
Adriana,Lori [19]
;
Jurjen J,Luykx [20]
;
Adam X,Maihofer [21]
;
William,Milberg [22]
;
Mark W,Miller [23]
;
Mary S,Mufford [24]
;
Nicole R,Nugent [25]
;
Sheila,Rauch [26]
;
Kerry J,Ressler [27]
;
Victoria B,Risbrough [21]
;
Bart P F,Rutten [28]
;
Dan J,Stein [17]
;
Murray B,Stein [29]
;
Robert J,Ursano [30]
;
Mieke H,Verfaellie [31]
;
Eric,Vermetten [32]
;
Christiaan H,Vinkers [33]
;
Erin B,Ware [34]
;
Derek E,Wildman [1]
;
Erika J,Wolf [35]
;
Caroline M,Nievergelt [21]
;
Mark W,Logue [36]
;
Alicia K,Smith [37]
;
Monica,Uddin [38]
作者单位：
Genomics Program, College of Public Health, University of South Florida, Tampa, FL, USA.
[1]
Department of Gynecology and Obstetrics, Emory University, Atlanta, GA, USA.
[2]
Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
[3]
Broad Institute of MIT and Harvard, Stanley Center for Psychiatric Research, Cambridge, MA, USA.;Department of Psychiatry, Harvard Medical School, Boston, MA, USA.;Center of Excellence in Depression and Anxiety Disorders, McLean Hospital, Belmont, MA, USA.
[4]
University of North Carolina at Chapel Hill, Carolina Stress Initiative, Chapel Hill, NC, USA.;Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.;Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.;Institute for Trauma Recovery, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
[5]
Robert N Butler Columbia Aging Center, Department of Epidemiology, Columbia University, New York, NY, USA.
[6]
Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.;Veterans Affairs San Diego Healthcare System, Center of Excellence for Stress and Mental Health, San Diego, CA, USA.;Veterans Affairs San Diego Healthcare System, Psychiatry Service, San Diego, CA, USA.
[7]
Department of Psychiatry, Brain Center University Medical Center Utrecht, Utrecht, UT, Netherlands.
[8]
Department of Psychiatry and Human Behavior, Warren Alpert Medical School of Brown University, Providence, RI, USA.
[9]
Biogen Inc., Translational Sciences, Cambridge, MA, USA.
[10]
Department of Pathology, University of Cape Town, Cape Town, Western Province, South Africa.;Division of Human Genetics, University of Cape Town, Cape Town, Western Province, South Africa.
[11]
Department of Psychiatry, Harvard Medical School, Boston, MA, USA.;VA Boston Healthcare System, TRACTS/GRECC, Boston, MA, USA.
[12]
Brain Research and Innovation Centre, Netherlands Ministry of Defence, Utrecht, UT, Netherlands.;Department of Psychiatry, UMC Utrecht Brain Center Rudolf Magnus, Utrecht, UT, Netherlands.
[13]
Department of Psychology, The Ohio State University, Columbus, OH, USA.
[14]
Department of Health Care Policy, Harvard Medical School, Boston, MA, USA.
[15]
The Ohio State University, College of Medicine, Institute for Behavioral Medicine Research, Columbus, OH, USA.
[16]
Department of Psychiatry & Mental Health, University of Cape Town, Cape Town, Western Province, South Africa.;University of Cape Town, Neuroscience Institute, Cape Town, Western Province, South Africa.;SA MRC Unit On Risk & Resilience in Mental Disorders, University of Cape Town, Cape Town, Western Province, South Africa.
[17]
Department of Psychiatry and Behavioral Sciences, Texas A&M University College of Medicine, Bryan, TX, USA.
[18]
Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA, USA.
[19]
Department of Psychiatry, UMC Utrecht Brain Center Rudolf Magnus, Utrecht, UT, Netherlands.;Department of Translational Neuroscience, UMC Utrecht Brain Center Rudolf Magnus, Utrecht, UT, Netherlands.
[20]
Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.;Veterans Affairs San Diego Healthcare System, Center of Excellence for Stress and Mental Health, San Diego, CA, USA.;Veterans Affairs San Diego Healthcare System, Research Service, San Diego, CA, USA.
[21]
VA Boston Healthcare System, GRECC/TRACTS, Boston, MA, USA.
[22]
Boston University School of Medicine, Psychiatry, Boston, MA, USA.;VA Boston Healthcare System, National Center for PTSD, Boston, MA, USA.
[23]
University of Cape Town, Neuroscience Institute, Cape Town, Western Province, South Africa.;Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, Western Province, South Africa.
[24]
Department of Emergency Medicine, Warren Alpert Brown Medical School, Providence, RI, USA.;Department of Pediatrics, Warren Alpert Brown Medical School, Providence, RI, USA.;Department of Psychiatry and Human Behavior, Warren Alpert Brown Medical School, Providence, RI, USA.
[25]
Department of Psychiatry & Behavioral Sciences, Emory University, Atlanta, GA, USA.;Joseph Maxwell Cleland Atlanta Veterans Affairs Medical Center, Mental Health Service Line, Atlanta, USA.
[26]
Department of Psychiatry, Harvard Medical School, Boston, MA, USA.;Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA, USA.;McLean Hospital, Belmont, MA, USA.
[27]
School for Mental Health and Neuroscience, Department of Psychiatry and Neuropsychology, Maastricht Universitair Medisch Centrum, Maastricht, Limburg, Netherlands.
[28]
Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.;Veterans Affairs San Diego Healthcare System, Psychiatry Service, San Diego, CA, USA.;School of Public Health, University of California San Diego, La Jolla, CA, USA.
[29]
Department of Psychiatry, Uniformed Services University, Bethesda, MD, USA.
[30]
Department of Psychiatry, Boston University School of Medicine, Boston, MA, USA.;VA Boston Healthcare System, Memory Disorders Research Center, Boston, MA, USA.
[31]
Department of Psychiatry, Leiden University Medical Center, Leiden, ZH, Netherlands.;Department of Psychiatry, New York University School of Medicine, New York, NY, USA.
[32]
Amsterdam Neuroscience, Mood, Anxiety, Psychosis, Sleep & Stress Program, Amsterdam, Holland, Netherlands.;Department of Anatomy and Neurosciences, Amsterdam UMC Location Vrije Universiteit Amsterdam, Amsterdam, Holland, Netherlands.;Department of Psychiatry, Amsterdam UMC Location Vrije Universiteit Amsterdam, Amsterdam, Holland, Netherlands.
[33]
Survey Research Center, University of Michigan, Institute for Social Research, Ann Arbor, MI, USA.
[34]
VA Boston Healthcare System, National Center for PTSD, Boston, MA, USA.;Department of Psychiatry, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.
[35]
Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.;VA Boston Healthcare System, National Center for PTSD, Boston, MA, USA.;Boston University School of Medicine, Psychiatry, Biomedical Genetics, Boston, MA, USA.
[36]
Department of Gynecology and Obstetrics, Emory University, Atlanta, GA, USA.;Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA, USA.;Department of Human Genetics, Emory University, Atlanta, GA, USA.
[37]
Genomics Program, College of Public Health, University of South Florida, Tampa, FL, USA. monica43@usf.edu.
[38]
医学主题词
人类(Humans);应激障碍, 创伤后(Stress Disorders, Post-Traumatic);DNA甲基化(DNA Methylation);男(雄)性(Male);军事人员(Military Personnel);女(雌)性(Female);成年人(Adult);队列研究(Cohort Studies);危险因素(Risk Factors);危险性评估(Risk Assessment);中年人(Middle Aged)
DOI
10.1186/s12920-024-02002-6
PMID
39334086
发布时间
2024-10-08
- 浏览1
BMC medical genomics
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