Development of a Formulation and In Vitro Evaluation of a Pulmonary Drug Delivery System for a Novel Janus Kinase (JAK) Inhibitor, CPL409116.

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第一作者： Aleksandra,Rzewińska

第一单位： Finished Dosage Forms Department, Research and Development Center, Celon Pharma S.A., Marymoncka 15, 05-052 Kazuń Nowy, Poland.;Department of Drug Technology and Pharmaceutical Biotechnology, Faculty of Pharmacy, Medical University of Warsaw, Banacha 1, 02-097 Warszawa, Poland.

作者： Aleksandra,Rzewińska ^[1] ; Jakub,Szlęk ^[2] ; Damian,Dąbrowski ^[3] ; Ewelina,Juszczyk ^[4] ; Katarzyna,Mróz ^[4] ; Heikki,Räikkönen ^[5] ; Mia,Siven ^[6] ; Maciej,Wieczorek ^[7] ; Przemysław,Dorożyński ^[8]

作者单位： Finished Dosage Forms Department, Research and Development Center, Celon Pharma S.A., Marymoncka 15, 05-052 Kazuń Nowy, Poland.;Department of Drug Technology and Pharmaceutical Biotechnology, Faculty of Pharmacy, Medical University of Warsaw, Banacha 1, 02-097 Warszawa, Poland. ^[1] Chair and Department of Pharmaceutical Technology and Biopharmaceutics, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30-688 Kraków, Poland. ^[2] Chair of Analytical Chemistry, Faculty of Chemistry, Warsaw University of Technology, Noakowskiego 3, 00-664 Warszawa, Poland. ^[3] Finished Dosage Forms Department, Research and Development Center, Celon Pharma S.A., Marymoncka 15, 05-052 Kazuń Nowy, Poland. ^[4] Faculty of Pharmacy, University of Helsinki, Viikinkaari 5, 00014 Helsinki, Finland. ^[5] Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Viikinkaari 5 E, 00014 Helsinki, Finland.;Helsinki Institute of Sustainability Science HELSUS, University of Helsinki, 00014 Helsinki, Finland. ^[6] Research and Development Center, Celon Pharma S.A., Marymoncka 15, 05-052 Kazuń Nowy, Poland. ^[7] Department of Drug Technology and Pharmaceutical Biotechnology, Faculty of Pharmacy, Medical University of Warsaw, Banacha 1, 02-097 Warszawa, Poland.;Department of Inorganic and Analytical Chemistry, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30-688 Kraków, Poland. ^[8]

关键词 Janus kinase (JAK) inhibitor jet milling (JM)micronization pulmonary drug delivery spray drying (SD)

DOI 10.3390/pharmaceutics16091157

PMID 39339194

发布时间 2024-09-30

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