Structural basis for the rescue of hyperexcitable cells by the amyotrophic lateral sclerosis drug Riluzole.

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作者： David,Hollingworth ^[1] ; Frances,Thomas ^[1] ; Dana A,Page ^[2] ; Mohamed A,Fouda ^[2] ; Raquel Lopez-Rios,De Castro ^[3] ; Altin,Sula ^[4] ; Vitaliy B,Mykhaylyk ^[5] ; Geoff,Kelly ^[6] ; Martin B,Ulmschneider ^[7] ; Peter C,Ruben ^[8] ; B A,Wallace ^[9]

作者单位： School of Natural Sciences, Birkbeck University of London, London, United Kingdom. ^[1] Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, BC, Canada. ^[2] Department of Chemistry, King's College London, London, United Kingdom.;Biological Physics and Soft Matter Group, Department of Physics, King's College London, London, United Kingdom. ^[3] Syngenta Crop Protection, Jealott's Hill International Research Centre, Bracknell, Berkshire, United Kingdom. ^[4] Diamond Light Source, Harwell Science and Innovation Campus, Chilton, Didcot, UK. ^[5] The Medical Research Council Biomedical NMR Centre, The Francis Crick Institute, London, UK. ^[6] Department of Chemistry, King's College London, London, United Kingdom. martin.ulmschneider@kcl.ac.uk. ^[7] Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, BC, Canada. pruben@sfu.ca. ^[8] School of Natural Sciences, Birkbeck University of London, London, United Kingdom. b.wallace@bbk.ac.uk. ^[9]