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Chemical genetic analysis of enoxolone inhibition of Clostridioides difficile toxin production reveals adenine deaminase and ATP synthase as antivirulence targets.

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第一作者： Ravi K R,Marreddy

第一单位： Center for Infectious and Inflammatory Diseases, Institute of Biosciences and Technology, Texas A&M Health Science Center, Houston, Texas, USA.

作者： Ravi K R,Marreddy ^[1] ; Gregory A,Phelps ^[2] ; Kelly,Churion ^[1] ; Jonathan,Picker ^[1] ; Reid,Powell ^[3] ; Philip T,Cherian ^[4] ; John J,Bowling ^[4] ; Clifford C,Stephan ^[3] ; Richard E,Lee ^[4] ; Julian G,Hurdle ^[5]

作者单位： Center for Infectious and Inflammatory Diseases, Institute of Biosciences and Technology, Texas A&M Health Science Center, Houston, Texas, USA. ^[1] Department of Chemical Biology and Therapeutics, St Jude Children's Research Hospital, Memphis, Tennessee, USA; Graduate School of Biomedical Sciences, St Jude Children's Research Hospital, Memphis, Tennessee, USA. ^[2] Center for Translational Cancer Research, Institute of Biosciences and Technology, Texas A&M Health Science Center, Houston, Texas, USA. ^[3] Department of Chemical Biology and Therapeutics, St Jude Children's Research Hospital, Memphis, Tennessee, USA. ^[4] Center for Infectious and Inflammatory Diseases, Institute of Biosciences and Technology, Texas A&M Health Science Center, Houston, Texas, USA. Electronic address: jhurdle@tamu.edu. ^[5]

关键词 ATP synthase adenine deaminase phosphate metabolism purine metabolism sporulation toxins

医学主题词细菌毒素类(Bacterial Toxins);细菌蛋白质类(Bacterial Proteins);肠毒素类(Enterotoxins);线粒体质子转运ATP酶(Mitochondrial Proton-Translocating ATPases);人类(Humans)

DOI 10.1016/j.jbc.2024.107839

PMID 39343002

发布时间 2025-06-11

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