换一批
换一批Impact of essential genes on the success of genome editing experiments generating 3313 new genetically engineered mouse lines.
作者：
Hillary,Elrick [1]
;
Kevin A,Peterson [2]
;
Brandon J,Willis [3]
;
Denise G,Lanza [4]
;
Elif F,Acar [5]
;
Edward J,Ryder [6]
;
Lydia,Teboul [7]
;
Petr,Kasparek [8]
;
Marie-Christine,Birling [9]
;
David J,Adams [10]
;
Allan,Bradley [11]
;
Robert E,Braun [2]
;
Steve D,Brown [12]
;
Adam,Caulder [7]
;
Gemma F,Codner [13]
;
Francesco J,DeMayo [14]
;
Mary E,Dickinson [15]
;
Brendan,Doe [16]
;
Graham,Duddy [16]
;
Marina,Gertsenstein [17]
;
Leslie O,Goodwin [2]
;
Yann,Hérault [9]
;
Lauri G,Lintott [1]
;
K C Kent,Lloyd [18]
;
Isabel,Lorenzo [4]
;
Matthew,Mackenzie [7]
;
Ann-Marie,Mallon [12]
;
Colin,McKerlie [19]
;
Helen,Parkinson [20]
;
Ramiro,Ramirez-Solis [21]
;
John R,Seavitt [22]
;
Radislav,Sedlacek [23]
;
William C,Skarnes [24]
;
Damien,Smedley [25]
;
Sara,Wells [7]
;
Jacqueline K,White [2]
;
Joshua A,Wood [26]
;
International Mouse Phenotyping Consortium [2]
;
Stephen A,Murray [4]
;
Jason D,Heaney [27]
;
Lauryl M J,Nutter
作者单位：
The Centre for Phenogenomics, Toronto, ON, M5T 3H7, Canada.;The Hospital for Sick Children, Toronto, ON, M5G 1X8, Canada.
[1]
The Jackson Laboratory, Bar Harbor, ME, 04609, USA.
[2]
Mouse Biology Program, University of California-Davis, Davis, CA, 95618, USA.
[3]
Department of Molecular and Human Genetic, Baylor College of Medicine, Houston, TX, 77030, USA.
[4]
The Centre for Phenogenomics, Toronto, ON, M5T 3H7, Canada.;The Hospital for Sick Children, Toronto, ON, M5G 1X8, Canada.;Department of Statistics, University of Manitoba, Winnipeg, MB, R3T 2N2, Canada.;Department of Mathematics and Statistics, University of Guelph, Guelph, ON, N1G 2W1, Canada.
[5]
Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.;LGC Assure, Fordham, CB7 5WW, UK.
[6]
The Mary Lyon Centre, MRC Harwell Institute, Harwell Campus, Didcot, Oxon, OX11 0RD, UK.
[7]
Czech Centre for Phenogenomics, Institute of Molecular Genetics of the Czech Academy of Sciences, Vestec, Czech Republic.;Program in Craniofacial Biology and Department of Orofacial Sciences, University of California, San Francisco, San Francisco, CA, USA.
[8]
CNRS, INSERM, CELPHEDIA, PHENOMIN, Institut Clinique de la Souris, Université de Strasbourg, Illkirch-Graffenstaden, France.
[9]
Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.
[10]
Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.;Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Trinity Lane, Cambridge, CB2 1TN, UK.
[11]
MRC Harwell Institute, Harwell, OX11 0RD, UK.
[12]
The Mary Lyon Centre, MRC Harwell Institute, Harwell Campus, Didcot, Oxon, OX11 0RD, UK.;Nuffield Department of Population Health, University of Oxford, Oxford, OX3 7LF, UK.
[13]
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, 77030, USA.;Reproductive and Developmental Biology Laboratory, NIEHS, Research Triangle Park, Durham, NC, 27709, USA.
[14]
Department of Integrative Physiology, Baylor College of Medicine, Houston, TX, 77030, USA.
[15]
Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.;The Francis Crick Institute, 1 Midland Rd, London, NW1 1AT, UK.
[16]
The Centre for Phenogenomics, Toronto, ON, M5T 3H7, Canada.
[17]
Mouse Biology Program, University of California-Davis, Davis, CA, 95618, USA.;Department of Surgery, School of Medicine, University of California Davis, Davis, CA, 95618, USA.
[18]
The Hospital for Sick Children, Toronto, ON, M5G 1X8, Canada.
[19]
European Molecular Biology Laboratory-European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, UK.
[20]
Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.;UT Health San Antonio, San Antonio, TX, 78229, USA.
[21]
The Jackson Laboratory, Bar Harbor, ME, 04609, USA.;Department of Molecular and Human Genetic, Baylor College of Medicine, Houston, TX, 77030, USA.
[22]
Czech Centre for Phenogenomics, Institute of Molecular Genetics of the Czech Academy of Sciences, Vestec, Czech Republic.
[23]
Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.;The Jackson Laboratory for Genomic Medicine, Farmington, CT, 06032, USA.
[24]
William Harvey Research Institute, Queen Mary University of London, London, EC1M 6BQ, UK.
[25]
The Jackson Laboratory, Bar Harbor, ME, 04609, USA.;Mouse Biology Program, University of California-Davis, Davis, CA, 95618, USA.
[26]
The Centre for Phenogenomics, Toronto, ON, M5T 3H7, Canada. lauryl.nutter@sickkids.ca.;The Hospital for Sick Children, Toronto, ON, M5G 1X8, Canada. lauryl.nutter@sickkids.ca.
[27]
主题词
动物(Animals);基因, 必要(Genes, Essential);小鼠(Mice);小鼠, 基因敲除(Mice, Knockout);等位基因(Alleles);小鼠, 近交C57BL(Mice, Inbred C57BL);男(雄)性(Male);女(雌)性(Female);遗传工程(Genetic Engineering);表型(Phenotype)
DOI
10.1038/s41598-024-72418-8
PMID
39349521
发布时间
2025-01-04
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