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Design, synthesis, in vitro and in silico studies of novel piperidine derived thiosemicarbazones as inhibitors of dihydrofolate reductase.

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第一作者： Hina,Aftab

第一单位： Institute of Chemical Sciences, Bahauddin Zakariya University, Multan, 60800, Pakistan.

作者： Hina,Aftab ^[1] ; Saeed,Ullah ^[2] ; Ajmal,Khan ^[3] ; Mariya,Al-Rashida ^[4] ; Talha,Islam ^[4] ; Kholood A,Dahlous ^[5] ; Saikh,Mohammad ^[5] ; Hamdy,Kashtoh ^[6] ; Ahmed,Al-Harrasi ^[7] ; Zahid,Shafiq ^[8]

作者单位： Institute of Chemical Sciences, Bahauddin Zakariya University, Multan, 60800, Pakistan. ^[1] Natural and Medical Sciences Research Centre, University of Nizwa, Birkat Al Mauz, P.O. Box 33, Nizwa, 616, Sultanate of Oman. ^[2] Natural and Medical Sciences Research Centre, University of Nizwa, Birkat Al Mauz, P.O. Box 33, Nizwa, 616, Sultanate of Oman.;Department of Chemical and Biological Engineering, College of Engineering, Korea University, 145 Anam-ro, Seongbuk-gu, 02841, Seoul, Republic of Korea. ^[3] Department of Chemistry, Forman Christian College (A Chartered University, Lahore, Pakistan. ^[4] Department of Chemistry, College of Science, King Saud University, Riyadh, 11451, Saudi Arabia. ^[5] Department of Biotechnology, Yeungnam University, Gyeongsan, Gyeongbuk, 38541, Republic of Korea. hamdy_kashtoh@ynu.ac.kr. ^[6] Natural and Medical Sciences Research Centre, University of Nizwa, Birkat Al Mauz, P.O. Box 33, Nizwa, 616, Sultanate of Oman. aharrasi@unizwa.edu.om. ^[7] Institute of Chemical Sciences, Bahauddin Zakariya University, Multan, 60800, Pakistan. zahidshafiq@bzu.edu.pk. ^[8]

关键词 ADME DHFR Enzyme inhibition MoLecular docking Piperidine Thiosemicarbazones