Chronic hypoxia drives the occurrence of ferroptosis in liver of fat greening (Hexagrammos otakii) by activating HIF-1α and promoting iron production.

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第一作者： Dongxu,Gao

第一单位： Key Laboratory of Applied Biology and Aquaculture of Northern Fishes in Liaoning Province, Dalian Ocean University, Dalian 116023, China; College of Fisheries and Life Science, Dalian Ocean University, Dalian 116023, China.

作者： Dongxu,Gao ^[1] ; Yiting,Wu ^[1] ; Yu,Zhan ^[1] ; Lei,Peng ^[1] ; Ling,Zhao ^[1] ; Shengnan,Cao ^[1] ; Zhuang,Xue ^[2] ; Wei,Wang ^[3]

作者单位： Key Laboratory of Applied Biology and Aquaculture of Northern Fishes in Liaoning Province, Dalian Ocean University, Dalian 116023, China; College of Fisheries and Life Science, Dalian Ocean University, Dalian 116023, China. ^[1] Key Laboratory of Applied Biology and Aquaculture of Northern Fishes in Liaoning Province, Dalian Ocean University, Dalian 116023, China; College of Fisheries and Life Science, Dalian Ocean University, Dalian 116023, China. Electronic address: xg-dzyx@163.com. ^[2] Key Laboratory of Applied Biology and Aquaculture of Northern Fishes in Liaoning Province, Dalian Ocean University, Dalian 116023, China; College of Fisheries and Life Science, Dalian Ocean University, Dalian 116023, China. Electronic address: wangwei@dlou.edu.cn. ^[3]

关键词 Ferroptosis Hexagrammos otakii Hypoxia Hypoxia-inducible factor-1α TFR1

主题词动物(Animals);缺氧诱导因子1, α亚基(Hypoxia-Inducible Factor 1, alpha Subunit);铁(Iron);脂质过氧化作用(Lipid Peroxidation);肝(Liver);活性氧(Reactive Oxygen Species);鱼类(Fishes)

DOI 10.1016/j.ecoenv.2024.117135

PMID 39353379

发布时间 2024-10-23

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