Loss of MACROD2 drives radioresistance but not cisplatin resistance in HPV-positive head and neck cancer.

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作者： Alice,Dawson ^[1] ; Amir Hossein,Karimi ^[1] ; Mushfiq H,Shaikh ^[2] ; Walid,Gazala ^[2] ; Peter Y F,Zeng ^[1] ; Sarah E B,Ryan ^[1] ; Harrison,Pan ^[1] ; Halema,Khan ^[2] ; Matthew,Cecchini ^[3] ; Adrian,Mendez ^[4] ; David A,Palma ^[4] ; Joe S,Mymryk ^[5] ; John W,Barrett ^[4] ; Anthony C,Nichols ^[6]

作者单位： Department of Otolaryngology - Head and Neck Surgery, University of Western Ontario, London, Ontario, Canada; Department of Pathology and Laboratory Medicine, University of Western Ontario, London, Ontario, Canada. ^[1] Department of Otolaryngology - Head and Neck Surgery, University of Western Ontario, London, Ontario, Canada. ^[2] Department of Pathology and Laboratory Medicine, University of Western Ontario, London, Ontario, Canada. ^[3] Department of Otolaryngology - Head and Neck Surgery, University of Western Ontario, London, Ontario, Canada; Department of Oncology, University of Western Ontario, London, Ontario, Canada. ^[4] Department of Otolaryngology - Head and Neck Surgery, University of Western Ontario, London, Ontario, Canada; Department of Oncology, University of Western Ontario, London, Ontario, Canada; Department of Microbiology & Immunology, University of Western Ontario, London, Ontario, Canada. ^[5] Department of Otolaryngology - Head and Neck Surgery, University of Western Ontario, London, Ontario, Canada; Department of Oncology, University of Western Ontario, London, Ontario, Canada. Electronic address: anthony.nichols@lhsc.on.ca. ^[6]

关键词 HPV Head and neck squamous cell carcinoma Hypoxia MACROD2 Radioresistance