Synergistic Gas Therapy and Targeted Interventional Ablation With Size-Controllable Arsenic Sulfide (As<sub>2</sub>S<sub>3</sub>) Nanoparticles for Effective Elimination of Localized Cancer Pain.

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作者： Yu,Tang ^[1] ; Jiyun,Zhang ^[1] ; Yuan,Yuan ^[1] ; Kele,Shen ^[1] ; Zhiyuan,Luo ^[2] ; Luyu,Jia ^[3] ; Xiaofeng,Long ^[1] ; Chi,Peng ^[1] ; Tian,Xie ^[4] ; Xiaoyuan,Chen ^[5] ; Pengfei,Zhang ^[1]

作者单位： Institute of Molecular Immunology, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou, 510000, China. ^[1] Institute of Molecular Immunology, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou, 510000, China.;Innovation Research Institute of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 200000, China. ^[2] Institute of Molecular Immunology, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou, 510000, China.;The Second Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, 510120, China. ^[3] Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines, Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou, Zhejiang, 310000, China. ^[4] Departments of Diagnostic Radiology, Surgery, Chemical and Biomolecular Engineering, and Biomedical Engineering, Clinical Imaging Research Centre, Nanomedicine Translational Research Program, Yong Loo Lin School of Medicine and Faculty of Engineering, National University of Singapore, Singapore, 119077, Singapore. ^[5]

关键词 H2S‐enhanced ROS damage arsenic nanodrugs arsenic sulfide nanoparticles cancer pain gas therapy mitochondrial damage size‐controllable metal sulfide nanoparticles