Calcineurin-mediated dephosphorylation stabilizes E2F1 protein by suppressing binding of the FBXW7 ubiquitin ligase subunit.

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第一作者： Yuki,Sato

第一单位： Department of Veterinary Biochemistry, Yamaguchi University, Yamaguchi 753-8511, Japan.

作者： Yuki,Sato ^[1] ; Makoto,Habara ^[1] ; Shunsuke,Hanaki ^[1] ; Takahiro,Masaki ^[1] ; Haruki,Tomiyasu ^[1] ; Yosei,Miki ^[1] ; Masashi,Sakurai ^[2] ; Masahiro,Morimoto ^[2] ; Daigo,Kobayashi ^[3] ; Tatsuo,Miyamoto ^[4] ; Midori,Shimada ^[5]

作者单位： Department of Veterinary Biochemistry, Yamaguchi University, Yamaguchi 753-8511, Japan. ^[1] Department of Veterinary Pathology, Yamaguchi University, Yamaguchi 753-8511, Japan. ^[2] Department of Molecular and Cellular Physiology, Graduate School of Medicine, Yamaguchi University, Ube, Yamaguchi 755-8505, Japan. ^[3] Department of Molecular and Cellular Physiology, Graduate School of Medicine, Yamaguchi University, Ube, Yamaguchi 755-8505, Japan.;Division of Advanced Genome Editing Therapy Research, Research Institute for Cell Design Medical Science, Yamaguchi University, Ube, Yamaguchi 755-8505, Japan. ^[4] Department of Veterinary Biochemistry, Yamaguchi University, Yamaguchi 753-8511, Japan.;Department of Molecular Biology, Graduate School of Medicine, Nagoya University, Nagoya, Aichi 466-8550, Japan. ^[5]

关键词 E2F1 FBXW7 calcium dephosphorylation protein stability