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Proximity-dependent labeling identifies dendritic cells that drive the tumor-specific CD4<sup>+</sup> T cell response.

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第一作者： Aleksey,Chudnovskiy

第一单位： Laboratory of Lymphocyte Dynamics, Rockefeller University, New York, NY, USA.

作者： Aleksey,Chudnovskiy ^[1] ; Tiago B R,Castro ^[1] ; Sandra,Nakandakari-Higa ^[1] ; Ang,Cui ^[2] ; Chia-Hao,Lin ^[3] ; Moshe,Sade-Feldman ^[4] ; Brooke K,Phillips ^[1] ; Juhee,Pae ^[1] ; Luka,Mesin ^[1] ; Juliana,Bortolatto ^[1] ; Lawrence D,Schweitzer ^[4] ; Giulia,Pasqual ^[5] ; Li-Fan,Lu ^[3] ; Nir,Hacohen ^[6] ; Gabriel D,Victora ^[1]

作者单位： Laboratory of Lymphocyte Dynamics, Rockefeller University, New York, NY, USA. ^[1] Broad Institute of MIT and Harvard, Cambridge, MA, USA.;Harvard School of Dental Medicine, Harvard University, Boston, MA, USA.;Harvard Medical School, Boston, MA, USA. ^[2] School of Biological Sciences, University of California, San Diego, La Jolla, CA, USA.;Moores Cancer Center, University of California, San Diego, La Jolla, CA, USA. ^[3] Broad Institute of MIT and Harvard, Cambridge, MA, USA. ^[4] Laboratory of Synthetic Immunology, Oncology and Immunology Section, Department of Surgery Oncology and Gastroenterology, University of Padua, Padua, Italy.;Veneto Institute of Oncology IOV-IRCCS, Padua, Italy. ^[5] Broad Institute of MIT and Harvard, Cambridge, MA, USA.;Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA. ^[6]

医学主题词动物(Animals);女(雌)性(Female);人类(Humans);小鼠(Mice);CD4阳性T淋巴细胞(CD4-Positive T-Lymphocytes);树突细胞(Dendritic Cells);小鼠, 近交C57BL(Mice, Inbred C57BL);肿瘤(Neoplasms);肿瘤微环境(Tumor Microenvironment);男(雄)性(Male)

DOI 10.1126/sciimmunol.adq8843

PMID 39365874

发布时间 2025-09-12

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Proximity-dependent labeling identifies dendritic cells that drive the tumor-specific CD4<sup>+</sup> T cell response.

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Proximity-dependent labeling identifies dendritic cells that drive the tumor-specific CD4<sup>+</sup> T cell response.

Science immunology

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