换一批
换一批The common VTE-protective G haplotype of F5 increases factor V-short, TFPI function, and risk of bleeding.
作者：
Matthew C,Sims [1]
;
Magdalena,Gierula [2]
;
Jonathan C,Stephens [3]
;
Alex,Tokolyi [4]
;
Luca,Stefanucci [5]
;
Elodie,Persyn [6]
;
Luanluan,Sun [7]
;
Janine H,Collins [8]
;
Emma E,Davenport [4]
;
Emanuele,Di Angelantonio [9]
;
Kate,Downes [10]
;
Michael,Inouye [11]
;
Dirk S,Paul [12]
;
Will,Thomas [13]
;
Alexander,Tolios [14]
;
Willem H,Ouwehand [15]
;
Nicholas S,Gleadall [16]
;
James T B,Crawley [2]
;
Adam S,Butterworth [17]
;
Mattia,Frontini [18]
;
Josefin,Ahnström [2]
作者单位：
Department of Haematology, University of Cambridge, Cambridge, United Kingdom.;National Health Service Blood and Transplant, Cambridge Biomedical Campus, Cambridge, United Kingdom.;Department of Haematology, Sheffield Teaching Hospitals National Health Service Foundation Trust, Sheffield, United Kingdom.;Clinical Medicine, School of Medicine and Population Health, University of Sheffield, Sheffield, United Kingdom.
[1]
Department of Immunology and Inflammation, Centre for Haematology, Imperial College London, London, United Kingdom.
[2]
Department of Haematology, University of Cambridge, Cambridge, United Kingdom.;National Institute for Health and Care Research BioResource, Cambridge University Hospitals, Cambridge Biomedical Campus, Cambridge, United Kingdom.
[3]
Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, United Kingdom.
[4]
Department of Haematology, University of Cambridge, Cambridge, United Kingdom.;National Health Service Blood and Transplant, Cambridge Biomedical Campus, Cambridge, United Kingdom.;British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge Biomedical Campus, Cambridge, United Kingdom.
[5]
Department of Public Health and Primary Care, British Heart Foundation Cardiovascular Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom.;Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge, United Kingdom.;Cambridge Baker Systems Genomics Initiative, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.
[6]
Department of Public Health and Primary Care, British Heart Foundation Cardiovascular Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom.
[7]
Department of Haematology, University of Cambridge, Cambridge, United Kingdom.;National Health Service Blood and Transplant, Cambridge Biomedical Campus, Cambridge, United Kingdom.;Department of Haematology, Barts Health National Health Service Trust, London, United Kingdom.
[8]
British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge Biomedical Campus, Cambridge, United Kingdom.;Department of Public Health and Primary Care, British Heart Foundation Cardiovascular Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom.;Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge, United Kingdom.;National Institute for Health and Care Research Blood and Transplant Research Unit in Donor Health and Behaviour, Cambridge, United Kingdom.;Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, United Kingdom.;Health Data Science Centre, Human Technopole, Milan, Italy.
[9]
Department of Haematology, University of Cambridge, Cambridge, United Kingdom.;National Health Service Blood and Transplant, Cambridge Biomedical Campus, Cambridge, United Kingdom.;Cambridge Genomics Laboratory, Cambridge University Hospitals National Health Service Foundation Trust, Cambridge Biomedical Campus, Cambridge, United Kingdom.
[10]
British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge Biomedical Campus, Cambridge, United Kingdom.;Department of Public Health and Primary Care, British Heart Foundation Cardiovascular Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom.;Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge, United Kingdom.;Cambridge Baker Systems Genomics Initiative, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.;Cambridge Baker Systems Genomics Initiative, Baker Heart and Diabetes Institute, Melbourne, VIC, Australia.
[11]
Department of Public Health and Primary Care, British Heart Foundation Cardiovascular Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom.;Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge, United Kingdom.;Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, United Kingdom.
[12]
Department of Haematology, Cambridge University Hospitals National Health Service Foundation Trust, Cambridge Biomedical Campus, Cambridge, United Kingdom.
[13]
Department of Transfusion Medicine and Cell Therapy, Medical University of Vienna, Vienna, Austria.
[14]
Department of Haematology, University of Cambridge, Cambridge, United Kingdom.;National Health Service Blood and Transplant, Cambridge Biomedical Campus, Cambridge, United Kingdom.;Department of Haematology, Cambridge University Hospitals National Health Service Foundation Trust, Cambridge Biomedical Campus, Cambridge, United Kingdom.;Department of Haematology, University College London Hospitals National Health Service Trust, London, United Kingdom.
[15]
Department of Haematology, University of Cambridge, Cambridge, United Kingdom.;National Health Service Blood and Transplant, Cambridge Biomedical Campus, Cambridge, United Kingdom.
[16]
British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge Biomedical Campus, Cambridge, United Kingdom.;Department of Public Health and Primary Care, British Heart Foundation Cardiovascular Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom.
[17]
Department of Haematology, University of Cambridge, Cambridge, United Kingdom.;National Health Service Blood and Transplant, Cambridge Biomedical Campus, Cambridge, United Kingdom.;British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge Biomedical Campus, Cambridge, United Kingdom.;Department of Clinical and Biomedical Sciences, University of Exeter Medical School, Exeter, United Kingdom.
[18]
主题词
人类(Humans);静脉血栓栓塞(Venous Thromboembolism);单倍型(Haplotypes);脂蛋白类(Lipoproteins);出血(Hemorrhage);因子Ⅴ(Factor V);男(雄)性(Male);女(雌)性(Female);多态性, 单核苷酸(Polymorphism, Single Nucleotide);疾病遗传易感性(Genetic Predisposition to Disease);危险因素(Risk Factors)
DOI
10.1182/bloodadvances.2024014020
PMID
39365993
发布时间
2024-12-31
- 浏览0
Blood advances
Blood advances
2025年9卷1期
132-142页
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