Cisplatin induces kidney damage through the down-regulation of Prx I by autophagic degradation.

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作者： Jiyoung,Park ^[1] ; Juhyun,Sim ^[2] ; Ho Jin,Yi ^[3] ; Sue Goo,Rhee ^[4] ; Hyun Ae,Woo ^[5]

作者单位： College of Pharmacy, Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul, 120-750, South Korea; Fluorescence Core Imaging Center, Department of Life Science, Ewha Womans University, Seoul, South Korea. Electronic address: jypark89@ewhain.net. ^[1] College of Pharmacy, Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul, 120-750, South Korea; National Forensic Service, 26460, 10 Ipchun-ro, Wonju, Gangwon-do, South Korea. Electronic address: jhsim86@korea.kr. ^[2] College of Pharmacy, Graduate School of Applied Science and Technology for Skin Health and Aesthetics, Ewha Womans University, Seoul, 120-750, South Korea. Electronic address: yihoz@naver.com. ^[3] Biochemistry and Biophysics Center, NHLBI, National Institutes of Health, Bethesda, MD, 20892, USA. Electronic address: rheesg249@yahoo.com. ^[4] College of Pharmacy, Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul, 120-750, South Korea; College of Pharmacy, Graduate School of Applied Science and Technology for Skin Health and Aesthetics, Ewha Womans University, Seoul, 120-750, South Korea. Electronic address: hawoo@ewha.ac.kr. ^[5]

关键词 Autophagy Cisplatin ER stress Nephrotoxicity Peroxiredoxin I