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Multi-ancestry GWAS meta-analyses of lung cancer reveal susceptibility loci and elucidate smoking-independent genetic risk.

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第一作者: Bryan R,Gorman
第一单位: Center for Data and Computational Sciences (C-DACS), VA Boston Healthcare System, Boston, MA, USA.;Booz Allen Hamilton, McLean, VA, USA.
作者单位: Center for Data and Computational Sciences (C-DACS), VA Boston Healthcare System, Boston, MA, USA.;Booz Allen Hamilton, McLean, VA, USA. [1] Center for Data and Computational Sciences (C-DACS), VA Boston Healthcare System, Boston, MA, USA.;BridgeBio Pharma, Palo Alto, CA, USA. [2] Center for Data and Computational Sciences (C-DACS), VA Boston Healthcare System, Boston, MA, USA.;Carbone Cancer Center, University of Wisconsin, Madison, WI, USA. [3] Center for Data and Computational Sciences (C-DACS), VA Boston Healthcare System, Boston, MA, USA. [4] Institute for Clinical and Translational Research, Baylor College of Medicine, Houston, TX, USA.;Department of Medicine, Section of Epidemiology and Population Sciences, Baylor College of Medicine, Houston, TX, USA. [5] The University of British Columbia Centre for Heart Lung Innovation, St Paul's Hospital, Vancouver, BC, Canada. [6] University Medical Centre Groningen, GRIAC (Groningen Research Institute for Asthma and COPD), University of Groningen, Groningen, Netherlands.;Department of Pathology & Medical Biology, University Medical Centre Groningen, University of Groningen, Groningen, Netherlands. [7] Office of Research and Development, Department of Veterans Affairs, Washington, DC, USA. [8] Lunenfeld-Tanenbaum Research Institute, Sinai Health System, University of Toronto, Toronto, ON, Canada. [9] Section of Genetics, International Agency for Research on Cancer, World Health Organization, Lyon, France. [10] Institut universitaire de cardiologie et de pneumologie de Québec, Department of Molecular Medicine, Laval University, Quebec City, QC, Canada. [11] Department of Biostatistics, University of Texas MD Anderson Cancer Center, Houston, TX, USA. [12] Institute for Clinical and Translational Research, Baylor College of Medicine, Houston, TX, USA.;Department of Medicine, Section of Epidemiology and Population Sciences, Baylor College of Medicine, Houston, TX, USA.;Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX, USA. [13] Center for Data and Computational Sciences (C-DACS), VA Boston Healthcare System, Boston, MA, USA. saiju.pyarajan@va.gov.;Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. saiju.pyarajan@va.gov. [14]
DOI 10.1038/s41467-024-52129-4
PMID 39366959
发布时间 2025-09-30
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