High Frequency of Artemisinin Partial Resistance Mutations in the Great Lakes Region Revealed Through Rapid Pooled Deep Sequencing.

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作者： Neeva,Wernsman Young ^[1] ; Pierre,Gashema ^[2] ; David,Giesbrecht ^[3] ; Tharcisse,Munyaneza ^[4] ; Felicien,Maisha ^[5] ; Fred,Mwebembezi ^[6] ; Rule,Budodo ^[7] ; Alec,Leonetti ^[3] ; Rebecca,Crudale ^[3] ; Vincent,Iradukunda ^[2] ; Ntwari,Jean Bosco ^[2] ; Rebecca I,Kirby ^[3] ; Ross M,Boyce ^[8] ; Celine I,Mandara ^[7] ; Grace K,Kanyankole ^[7] ; Moses,Ntaro ^[6] ; Lucy C,Okell ^[9] ; Oliver J,Watson ^[9] ; Edgar,Mulogo ^[6] ; Deus S,Ishengoma ^[10] ; Stan,Hangi ^[5] ; Corine,Karema ^[11] ; Jean-Baptiste,Mazarati ^[2] ; Jonathan J,Juliano ^[8] ; Jeffrey A,Bailey ^[1]

作者单位： Pathology and Laboratory Medicine, Brown University, Providence, Rhode Island.;Center for Computational and Molecular Biology, Brown University, Providence, Rhode Island. ^[1] Center for Genomic Biology, Institut d'Enseignement Supérieur de Ruhengeri, Ruhengeri, Rwanda. ^[2] Pathology and Laboratory Medicine, Brown University, Providence, Rhode Island. ^[3] National Reference Laboratory, Rwanda Biomedical Center, Kigali. ^[4] Department of Pediatrics, HEAL Africa Hospital, Goma, Democratic Republic of the Congo. ^[5] Department of Community Health, Mbarara University of Science and Technology, Uganda. ^[6] National Institute for Medical Research, Dar es Salaam, Tanzania. ^[7] Institute for Global Health and Infectious Diseases, University of North Carolina, Chapel Hill. ^[8] MRC Centre for Global Infectious Disease Analysis, Faculty of Medicine, Imperial College London, United Kingdom. ^[9] National Institute for Medical Research, Dar es Salaam, Tanzania.;Department of Biochemistry, Kampala International University in Tanzania, Dar es Salaam. ^[10] Quality Equity Health Care, Kigali, Rwanda. ^[11]

关键词 East Africa artemisinin drug resistance kelch13 malaria