Loss of heterozygosity of CYP2D6 enhances the sensitivity of hepatocellular carcinomas to talazoparib.

导出 LinkOut

翻译打印收藏纠错

作者： Xiaonan,Zhang ^[1] ; Natallia,Rameika ^[1] ; Lei,Zhong ^[1] ; Verónica,Rendo ^[1] ; Margus,Veanes ^[1] ; Snehangshu,Kundu ^[1] ; Sandro,Nuciforo ^[2] ; Jordan,Dupuis ^[1] ; Muhammad,Al Azhar ^[1] ; Ioanna,Tsiara ^[3] ; Pauline,Seeburger ^[3] ; Shahed,Al Nassralla ^[1] ; Viktor,Ljungström ^[1] ; Richard,Svensson ^[4] ; Ivaylo,Stoimenov ^[1] ; Per,Artursson ^[5] ; Markus H,Heim ^[6] ; Daniel,Globisch ^[3] ; Tobias,Sjöblom ^[7]

作者单位： Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, SE-751 85, Uppsala, Sweden. ^[1] Department of Biomedicine, University Hospital and University of Basel, CH-4031, Basel, Switzerland. ^[2] Department of Chemistry-BMC, Science for Life Laboratory, Uppsala University, SE-751 23, Uppsala, Sweden. ^[3] Uppsala Drug Optimization and Pharmaceutical Profiling Facility (UDOPP), SciLifeLab Chemical Biology Consortium Sweden (CBCS), Department of Pharmacy, Uppsala University, 751 23, Uppsala, Sweden; Department of Pharmacy, Uppsala University, Husargatan 3, 751 23, Uppsala, Sweden. ^[4] Department of Pharmacy, Uppsala University, Husargatan 3, 751 23, Uppsala, Sweden. ^[5] Department of Biomedicine, University Hospital and University of Basel, CH-4031, Basel, Switzerland; Clarunis University Center for Gastrointestinal and Liver Diseases, CH-4002, Basel, Switzerland. ^[6] Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, SE-751 85, Uppsala, Sweden. Electronic address: tobias.sjoblom@igp.uu.se. ^[7]

关键词 CYP2D6 and talazoparib Hepatocellular carcinomas Loss of function Loss of heterozygosity

主题词人类(Humans);杂合子丢失(Loss of Heterozygosity);癌, 肝细胞(Carcinoma, Hepatocellular);肝肿瘤(Liver Neoplasms);细胞色素P450 CYP2D6(Cytochrome P-450 CYP2D6);酞嗪类(Phthalazines);细胞系, 肿瘤(Cell Line, Tumor);抗肿瘤药(Antineoplastic Agents);等位基因(Alleles);抗药性, 肿瘤(Drug Resistance, Neoplasm)

DOI 10.1016/j.ebiom.2024.105368

PMID 39368455

发布时间 2024-11-16

翻译满意度评价：

准确一般字义偏差语意偏离译文作用小提交

浏览0

EBioMedicine

2024年109卷

105368页

相似文献

中文期刊
外文期刊
学位论文
会议论文

检索历史清除

Loss of heterozygosity of CYP2D6 enhances the sensitivity of hepatocellular carcinomas to talazoparib.

EBioMedicine

相似文献

EBioMedicine

相关期刊

参考文献：
指定格式：	NoteExpress EndNote RefWorks NoteFirst

检索历史 清除

Loss of heterozygosity of CYP2D6 enhances the sensitivity of hepatocellular carcinomas to talazoparib.

EBioMedicine

相似文献

EBioMedicine

相关期刊

检索历史清除