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Discovery of a nasal spray steroid, tixocortol, as an inhibitor of SARS-CoV-2 main protease and viral replication.

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第一作者： David A,Davis

第一单位： HIV and AIDS Malignancy Branch, Center for Cancer Research, National Cancer Institute Bethesda MD USA david.davis@nih.gov.

作者： David A,Davis ^[1] ; Ashwin,Nair ^[1] ; Yana,Astter ^[1] ; Emma,Treco ^[1] ; Brian,Peyser ^[2] ; Rick,Gussio ^[3] ; Tam,Nguyen ^[2] ; Brett,Eaton ^[4] ; Elena,Postnikova ^[4] ; Michael,Murphy ^[4] ; Prabha,Shrestha ^[1] ; Haydar,Bulut ^[1] ; Shin-Ichiro,Hattorri ^[5] ; Hiroaki,Mitsuya ^[6] ; Robert,Yarchoan ^[1]

作者单位： HIV and AIDS Malignancy Branch, Center for Cancer Research, National Cancer Institute Bethesda MD USA david.davis@nih.gov. ^[1] Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, National Institutes of Health USA. ^[2] Vaccine Branch, Center for Cancer Research, National Cancer Institute, Frederick National Laboratory for Cancer Research Frederick MD 21702 USA.;Computational Institute for Health and Environmental Research, (CIFHER.ORG) Riverside 5, RM 4076, 8490 Progress Dr. Frederick MD 21701 USA. ^[3] Integrated Research Facility at Fort Detrick 8200 Research Plaza Frederick MD 21702 USA. ^[4] Department of Refractory Viral Infections, National Center for Global Health and Medicine Research Institute 1-21-1 Toyama Shinjuku-ku Tokyo 162-8655 Japan. ^[5] HIV and AIDS Malignancy Branch, Center for Cancer Research, National Cancer Institute Bethesda MD USA david.davis@nih.gov.;Department of Refractory Viral Infections, National Center for Global Health and Medicine Research Institute 1-21-1 Toyama Shinjuku-ku Tokyo 162-8655 Japan. ^[6]

DOI 10.1039/d4md00454j

PMID 39371432

发布时间 2025-05-30

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Discovery of a nasal spray steroid, tixocortol, as an inhibitor of SARS-CoV-2 main protease and viral replication.

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Discovery of a nasal spray steroid, tixocortol, as an inhibitor of SARS-CoV-2 main protease and viral replication.

RSC medicinal chemistry

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RSC medicinal chemistry

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