Senescent cell transplantation into the skin induces age-related peripheral dysfunction and cognitive decline.

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第一作者： Ana Catarina,Franco

第一单位： Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, USA.;Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota, USA.;CNC-Center for Neuroscience and Cell Biology (CNC-UC), University of Coimbra, Coimbra, Portugal.;Centre for Innovation in Biomedicine and Biotechnology (CIBB), University of Coimbra, Coimbra, Portugal.;Faculty of Pharmacy, University of Coimbra, Coimbra, Portugal.

作者： Ana Catarina,Franco ^[1] ; Helene,Martini ^[2] ; Stella,Victorelli ^[2] ; Anthony B,Lagnado ^[2] ; Saranya P,Wyles ^[3] ; Jennifer L,Rowsey ^[4] ; Nicholas,Pirius ^[2] ; Seung-Hwa,Woo ^[2] ; Daniela G,Costa ^[1] ; Selim,Chaib ^[5] ; Stefan G,Tullius ^[6] ; Tamar,Tchkonia ^[5] ; James L,Kirkland ^[5] ; Sundeep,Khosla ^[4] ; Diana,Jurk ^[7] ; Claudia,Cavadas ^[8] ; João F,Passos ^[2]

作者单位： Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, USA.;Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota, USA.;CNC-Center for Neuroscience and Cell Biology (CNC-UC), University of Coimbra, Coimbra, Portugal.;Centre for Innovation in Biomedicine and Biotechnology (CIBB), University of Coimbra, Coimbra, Portugal.;Faculty of Pharmacy, University of Coimbra, Coimbra, Portugal. ^[1] Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, USA.;Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota, USA. ^[2] Department of Dermatology, Mayo Clinic, Rochester, Minnesota, USA. ^[3] Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota, USA. ^[4] Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, USA.;Center for Advanced Gerotherapeutics, Division of Endocrinology, Diabetes & Metabolism, Cedars-Sinai Medical Center, Los Angeles, CA, USA. ^[5] Division of Transplant Surgery, Department of Surgery, Harvard Medical School, Brigham and Women's Hospital, Boston, Massachusetts, USA. ^[6] Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, USA.;Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota, USA.;Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA. ^[7] CNC-Center for Neuroscience and Cell Biology (CNC-UC), University of Coimbra, Coimbra, Portugal.;Centre for Innovation in Biomedicine and Biotechnology (CIBB), University of Coimbra, Coimbra, Portugal.;Faculty of Pharmacy, University of Coimbra, Coimbra, Portugal. ^[8]

关键词 cellular senescence cognitive decline paracrine senescence skin aging

主题词动物(Animals);小鼠(Mice);皮肤(Skin);衰老(Aging);成纤维细胞(Fibroblasts);小鼠, 近交C57BL(Mice, Inbred C57BL);男(雄)性(Male)

DOI 10.1111/acel.14340

PMID 39374134

发布时间 2025-01-10

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