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GeneCompass: deciphering universal gene regulatory mechanisms with a knowledge-informed cross-species foundation model.

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作者: Xiaodong,Yang [1] ; Guole,Liu [2] ; Guihai,Feng [3] ; Dechao,Bu [4] ; Pengfei,Wang [5] ; Jie,Jiang [6] ; Shubai,Chen [7] ; Qinmeng,Yang [8] ; Hefan,Miao [9] ; Yiyang,Zhang [10] ; Zhenpeng,Man [10] ; Zhongming,Liang [10] ; Zichen,Wang [2] ; Yaning,Li [7] ; Zheng,Li [8] ; Yana,Liu [11] ; Yao,Tian [9] ; Wenhao,Liu [11] ; Cong,Li [9] ; Ao,Li [2] ; Jingxi,Dong [11] ; Zhilong,Hu [5] ; Chen,Fang [9] ; Lina,Cui [9] ; Zixu,Deng [7] ; Haiping,Jiang [9] ; Wentao,Cui [5] ; Jiahao,Zhang [10] ; Zhaohui,Yang [4] ; Handong,Li [12] ; Xingjian,He [6] ; Liqun,Zhong [2] ; Jiaheng,Zhou [2] ; Zijian,Wang [8] ; Qingqing,Long [8] ; Ping,Xu [5] ; X-Compass Consortium [3] ; Hongmei,Wang [5] ; Zhen,Meng [5] ; Xuezhi,Wang [5] ; Yangang,Wang [10] ; Yong,Wang [10] ; Shihua,Zhang [13] ; Jingtao,Guo [14] ; Yi,Zhao [15] ; Yuanchun,Zhou [16] ; Fei,Li [17] ; Jing,Liu [18] ; Yiqiang,Chen [19] ; Ge,Yang [20] ; Xin,Li
作者单位: State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.;Beijing Key Laboratory of Mobile Computing and Pervasive Device, Institute of Computing Technology, Chinese Academy of Sciences, Beijing, China.;University of Chinese Academy of Sciences, Beijing, China. [1] State Key Laboratory of Multimodal Artificial Intelligence Systems, Institute of Automation, Chinese Academy of Sciences, Beijing, China.;School of Artificial Intelligence, University of Chinese Academy of Sciences, Beijing, China. [2] State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.;Institute for Stem Cell and Regenerative Medicine, Chinese Academy of Sciences, Beijing, China.;Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, China. [3] Beijing Key Laboratory of Mobile Computing and Pervasive Device, Institute of Computing Technology, Chinese Academy of Sciences, Beijing, China.;University of Chinese Academy of Sciences, Beijing, China.;Research Center for Ubiquitous Computing Systems, Institute of Computing Technology, Chinese Academy of Sciences, Beijing, China. [4] University of Chinese Academy of Sciences, Beijing, China.;Computer Network Information Center, Chinese Academy of Sciences, Beijing, China. [5] Institute of Automation, Chinese Academy of Sciences, Beijing, China. [6] Beijing Key Laboratory of Mobile Computing and Pervasive Device, Institute of Computing Technology, Chinese Academy of Sciences, Beijing, China.;University of Chinese Academy of Sciences, Beijing, China. [7] Computer Network Information Center, Chinese Academy of Sciences, Beijing, China. [8] State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.;University of Chinese Academy of Sciences, Beijing, China. [9] University of Chinese Academy of Sciences, Beijing, China.;CEMS, NCMIS, HCMS, MDIS, RCSDS, Academy of Mathematics and Systems Science, Chinese Academy of Sciences, Beijing, China. [10] State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China. [11] School of Artificial Intelligence, University of Chinese Academy of Sciences, Beijing, China.;Institute of Automation, Chinese Academy of Sciences, Beijing, China. [12] State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.;University of Chinese Academy of Sciences, Beijing, China.;Institute for Stem Cell and Regenerative Medicine, Chinese Academy of Sciences, Beijing, China.;Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, China. [13] Beijing Key Laboratory of Mobile Computing and Pervasive Device, Institute of Computing Technology, Chinese Academy of Sciences, Beijing, China. biozy@ict.ac.cn.;University of Chinese Academy of Sciences, Beijing, China. biozy@ict.ac.cn.;Research Center for Ubiquitous Computing Systems, Institute of Computing Technology, Chinese Academy of Sciences, Beijing, China. biozy@ict.ac.cn. [14] University of Chinese Academy of Sciences, Beijing, China. zyc@cnic.cn.;Computer Network Information Center, Chinese Academy of Sciences, Beijing, China. zyc@cnic.cn. [15] University of Chinese Academy of Sciences, Beijing, China. lifei@cnic.cn.;Computer Network Information Center, Chinese Academy of Sciences, Beijing, China. lifei@cnic.cn. [16] School of Artificial Intelligence, University of Chinese Academy of Sciences, Beijing, China. jliu@nlpr.ia.ac.cn.;Institute of Automation, Chinese Academy of Sciences, Beijing, China. jliu@nlpr.ia.ac.cn. [17] Beijing Key Laboratory of Mobile Computing and Pervasive Device, Institute of Computing Technology, Chinese Academy of Sciences, Beijing, China. yqchen@ict.ac.cn.;University of Chinese Academy of Sciences, Beijing, China. yqchen@ict.ac.cn. [18] State Key Laboratory of Multimodal Artificial Intelligence Systems, Institute of Automation, Chinese Academy of Sciences, Beijing, China. ge.yang@ia.ac.cn.;School of Artificial Intelligence, University of Chinese Academy of Sciences, Beijing, China. ge.yang@ia.ac.cn. [19] State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China. xinli@ioz.ac.cn.;University of Chinese Academy of Sciences, Beijing, China. xinli@ioz.ac.cn.;Institute for Stem Cell and Regenerative Medicine, Chinese Academy of Sciences, Beijing, China. xinli@ioz.ac.cn.;Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, China. xinli@ioz.ac.cn. [20]
DOI 10.1038/s41422-024-01034-y
PMID 39375485
发布时间 2024-12-12
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