GeneCompass: deciphering universal gene regulatory mechanisms with a knowledge-informed cross-species foundation model.
作者:
Xiaodong,Yang [1]
;
Guole,Liu [2]
;
Guihai,Feng [3]
;
Dechao,Bu [4]
;
Pengfei,Wang [5]
;
Jie,Jiang [6]
;
Shubai,Chen [7]
;
Qinmeng,Yang [8]
;
Hefan,Miao [9]
;
Yiyang,Zhang [10]
;
Zhenpeng,Man [10]
;
Zhongming,Liang [10]
;
Zichen,Wang [2]
;
Yaning,Li [7]
;
Zheng,Li [8]
;
Yana,Liu [11]
;
Yao,Tian [9]
;
Wenhao,Liu [11]
;
Cong,Li [9]
;
Ao,Li [2]
;
Jingxi,Dong [11]
;
Zhilong,Hu [5]
;
Chen,Fang [9]
;
Lina,Cui [9]
;
Zixu,Deng [7]
;
Haiping,Jiang [9]
;
Wentao,Cui [5]
;
Jiahao,Zhang [10]
;
Zhaohui,Yang [4]
;
Handong,Li [12]
;
Xingjian,He [6]
;
Liqun,Zhong [2]
;
Jiaheng,Zhou [2]
;
Zijian,Wang [8]
;
Qingqing,Long [8]
;
Ping,Xu [5]
;
X-Compass Consortium [3]
;
Hongmei,Wang [5]
;
Zhen,Meng [5]
;
Xuezhi,Wang [5]
;
Yangang,Wang [10]
;
Yong,Wang [10]
;
Shihua,Zhang [13]
;
Jingtao,Guo [14]
;
Yi,Zhao [15]
;
Yuanchun,Zhou [16]
;
Fei,Li [17]
;
Jing,Liu [18]
;
Yiqiang,Chen [19]
;
Ge,Yang [20]
;
Xin,Li
作者单位:
State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.;Beijing Key Laboratory of Mobile Computing and Pervasive Device, Institute of Computing Technology, Chinese Academy of Sciences, Beijing, China.;University of Chinese Academy of Sciences, Beijing, China.
[1]
State Key Laboratory of Multimodal Artificial Intelligence Systems, Institute of Automation, Chinese Academy of Sciences, Beijing, China.;School of Artificial Intelligence, University of Chinese Academy of Sciences, Beijing, China.
[2]
State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.;Institute for Stem Cell and Regenerative Medicine, Chinese Academy of Sciences, Beijing, China.;Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, China.
[3]
Beijing Key Laboratory of Mobile Computing and Pervasive Device, Institute of Computing Technology, Chinese Academy of Sciences, Beijing, China.;University of Chinese Academy of Sciences, Beijing, China.;Research Center for Ubiquitous Computing Systems, Institute of Computing Technology, Chinese Academy of Sciences, Beijing, China.
[4]
University of Chinese Academy of Sciences, Beijing, China.;Computer Network Information Center, Chinese Academy of Sciences, Beijing, China.
[5]
Institute of Automation, Chinese Academy of Sciences, Beijing, China.
[6]
Beijing Key Laboratory of Mobile Computing and Pervasive Device, Institute of Computing Technology, Chinese Academy of Sciences, Beijing, China.;University of Chinese Academy of Sciences, Beijing, China.
[7]
Computer Network Information Center, Chinese Academy of Sciences, Beijing, China.
[8]
State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.;University of Chinese Academy of Sciences, Beijing, China.
[9]
University of Chinese Academy of Sciences, Beijing, China.;CEMS, NCMIS, HCMS, MDIS, RCSDS, Academy of Mathematics and Systems Science, Chinese Academy of Sciences, Beijing, China.
[10]
State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.
[11]
School of Artificial Intelligence, University of Chinese Academy of Sciences, Beijing, China.;Institute of Automation, Chinese Academy of Sciences, Beijing, China.
[12]
State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.;University of Chinese Academy of Sciences, Beijing, China.;Institute for Stem Cell and Regenerative Medicine, Chinese Academy of Sciences, Beijing, China.;Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, China.
[13]
Beijing Key Laboratory of Mobile Computing and Pervasive Device, Institute of Computing Technology, Chinese Academy of Sciences, Beijing, China. biozy@ict.ac.cn.;University of Chinese Academy of Sciences, Beijing, China. biozy@ict.ac.cn.;Research Center for Ubiquitous Computing Systems, Institute of Computing Technology, Chinese Academy of Sciences, Beijing, China. biozy@ict.ac.cn.
[14]
University of Chinese Academy of Sciences, Beijing, China. zyc@cnic.cn.;Computer Network Information Center, Chinese Academy of Sciences, Beijing, China. zyc@cnic.cn.
[15]
University of Chinese Academy of Sciences, Beijing, China. lifei@cnic.cn.;Computer Network Information Center, Chinese Academy of Sciences, Beijing, China. lifei@cnic.cn.
[16]
School of Artificial Intelligence, University of Chinese Academy of Sciences, Beijing, China. jliu@nlpr.ia.ac.cn.;Institute of Automation, Chinese Academy of Sciences, Beijing, China. jliu@nlpr.ia.ac.cn.
[17]
Beijing Key Laboratory of Mobile Computing and Pervasive Device, Institute of Computing Technology, Chinese Academy of Sciences, Beijing, China. yqchen@ict.ac.cn.;University of Chinese Academy of Sciences, Beijing, China. yqchen@ict.ac.cn.
[18]
State Key Laboratory of Multimodal Artificial Intelligence Systems, Institute of Automation, Chinese Academy of Sciences, Beijing, China. ge.yang@ia.ac.cn.;School of Artificial Intelligence, University of Chinese Academy of Sciences, Beijing, China. ge.yang@ia.ac.cn.
[19]
State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China. xinli@ioz.ac.cn.;University of Chinese Academy of Sciences, Beijing, China. xinli@ioz.ac.cn.;Institute for Stem Cell and Regenerative Medicine, Chinese Academy of Sciences, Beijing, China. xinli@ioz.ac.cn.;Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, China. xinli@ioz.ac.cn.
[20]
主题词
人类(Humans);动物(Animals);小鼠(Mice);细胞分化(Cell Differentiation);单细胞分析(Single-Cell Analysis);基因表达调控(Gene Expression Regulation);基因调控网络(Gene Regulatory Networks);种特异性(Species Specificity)
DOI
10.1038/s41422-024-01034-y
PMID
39375485
发布时间
2024-12-12
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Cell research
Cell research
830-845页
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