Increased peritoneal TGF-β1 is associated with ascites-induced NK-cell dysfunction and reduced survival in high-grade epithelial ovarian cancer.

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第一作者： Ralph J A,Maas

第一单位： Laboratory of Hematology - Department of Laboratory Medicine, Radboud University Medical Center, Nijmegen, Netherlands.

作者： Ralph J A,Maas ^[1] ; Janneke S,Hoogstad-van Evert ^[2] ; Iris M,Hagemans ^[1] ; Jolanda,Brummelman ^[1] ; Diede,van Ens ^[1] ; Paul K J D,de Jonge ^[1] ; Laura,Hooijmaijers ^[1] ; Shweta,Mahajan ^[1] ; Anniek B,van der Waart ^[1] ; Charlotte K J C,Hermans ^[1] ; Janne,de Klein ^[1] ; Rob,Woestenenk ^[1] ; Antonius E,van Herwaarden ^[3] ; Nicolaas P M,Schaap ^[4] ; Somayeh,Rezaeifard ^[5] ; Daniele V F,Tauriello ^[6] ; Petra L M,Zusterzeel ^[7] ; Nelleke,Ottevanger ^[8] ; Joop H,Jansen ^[1] ; Willemijn,Hobo ^[1] ; Harry,Dolstra ^[1]

作者单位： Laboratory of Hematology - Department of Laboratory Medicine, Radboud University Medical Center, Nijmegen, Netherlands. ^[1] Laboratory of Hematology - Department of Laboratory Medicine, Radboud University Medical Center, Nijmegen, Netherlands.;Department of Obstetrics and Gynecology Amphia, Breda, Netherlands. ^[2] Diagnostic Laboratory - Department of Laboratory Medicine, Radboud University Medical Center, Nijmegen, Netherlands. ^[3] Department of Hematology, Radboud University Medical Center, Nijmegen, Netherlands. ^[4] Laboratory of Hematology - Department of Laboratory Medicine, Radboud University Medical Center, Nijmegen, Netherlands.;Department of Cell Biology, Radboud University Medical Center, Nijmegen, Netherlands. ^[5] Department of Cell Biology, Radboud University Medical Center, Nijmegen, Netherlands. ^[6] Department of Obstetrics and Gynecology, Radboud University Medical Center, Nijmegen, Netherlands. ^[7] Department of Medical Oncology, Radboud University Medical Center, Nijmegen, Netherlands. ^[8]

关键词 TGF-β ascites natural killer (NK) cells ovarian cancer tumor microenvironment