Oral administration of Sophora Flavescens-derived exosomes-like nanovesicles carrying CX5461 ameliorates DSS-induced colitis in mice.

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第一作者： Manqi,Zhang

第一单位： School of Pharmaceutical Sciences (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Gongchang Road, Shenzhen, Guangdong, 518107, China.

作者： Manqi,Zhang ^[1] ; Xichao,Xu ^[2] ; Liqian,Su ^[3] ; Yuqing,Zeng ^[1] ; Jingxiong,Lin ^[1] ; Wenwen,Li ^[4] ; Yigui,Zou ^[4] ; Sicong,Li ^[4] ; Boxian,Lin ^[4] ; Ziyuan,Li ^[4] ; Hu,Chen ^[4] ; Yuheng,Huang ^[1] ; Quanle,Xu ^[5] ; Hongbo,Chen ^[6] ; Fang,Cheng ^[7] ; Dongling,Dai ^[8]

作者单位： School of Pharmaceutical Sciences (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Gongchang Road, Shenzhen, Guangdong, 518107, China. ^[1] Endoscopy Center and Gastroenterology Department, Key Laboratory for Precision Diagnosis and Treatment of Pediatric Digestive System Diseases, Shenzhen Children's Hospital, Shenzhen, 518036, China.;Brain Cognition and Brain Disease Institute, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518052, China. ^[2] Endoscopy Center and Gastroenterology Department, Key Laboratory for Precision Diagnosis and Treatment of Pediatric Digestive System Diseases, Shenzhen Children's Hospital, Shenzhen, 518036, China.;College of Life Sciences, Northwest A&F University, Yangling, Shaanxi, 712100, China. ^[3] Endoscopy Center and Gastroenterology Department, Key Laboratory for Precision Diagnosis and Treatment of Pediatric Digestive System Diseases, Shenzhen Children's Hospital, Shenzhen, 518036, China. ^[4] College of Life Sciences, Northwest A&F University, Yangling, Shaanxi, 712100, China. ^[5] School of Pharmaceutical Sciences (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Gongchang Road, Shenzhen, Guangdong, 518107, China. chenhb7@mail.sysu.edu.cn. ^[6] School of Pharmaceutical Sciences (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Gongchang Road, Shenzhen, Guangdong, 518107, China. chengf9@mail.sysu.edu.cn. ^[7] Endoscopy Center and Gastroenterology Department, Key Laboratory for Precision Diagnosis and Treatment of Pediatric Digestive System Diseases, Shenzhen Children's Hospital, Shenzhen, 518036, China. daidong3529@sina.com. ^[8]

关键词 Sophora Flavescens-derived exosomes-like nanovesicles CX5461 Inflammation Macrophage Ulcerative colitis