Signal peptide exchange alters HIV-1 envelope antigenicity and immunogenicity.

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作者： Chitra,Upadhyay ^[1] ; Priyanka,Rao ^[1] ; Mohammad Amin,Behzadi ^[2] ; Roya,Feyznezhad ^[1] ; Gregory S,Lambert ^[1] ; Rajnish,Kumar ^[1] ; Madhu,Kumar ^[2] ; Weiming,Yang ^[3] ; Xunqing,Jiang ^[4] ; Christina C,Luo ^[4] ; Arthur,Nadas ^[5] ; James,Arthos ^[6] ; Xiang-Peng,Kong ^[4] ; Hui,Zhang ^[3] ; Catarina E,Hioe ^[7] ; J Andrew,Duty ^[2]

作者单位： Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States. ^[1] Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, United States. ^[2] Department of Pathology, Johns Hopkins University, Baltimore, MD, United States. ^[3] Department of Biochemistry and Molecular Pharmacology, New York University Grossman School of Medicine, New York, NY, United States. ^[4] Department of Environment Medicine, New York University Grossman School of Medicine, New York, NY, United States. ^[5] National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States. ^[6] Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States.;Research Service, James J. Peters VA Medical Center, Bronx, NY, United States. ^[7]

关键词 HIV-1 envelope HIV-1 vaccine antibody-dependent cellular phagocytosis antigenicity glycosylation immunogenicity neutralization signal peptide