Forsythoside A mitigates osteoarthritis and inhibits chondrocyte senescence by promoting mitophagy and suppressing NLRP3 inflammasome via the Nrf2 pathway.

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第一作者： Wei,Li

第一单位： Department of Sports Medicine, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China; Guangdong Provincial Key Laboratory of Orthopedics and Traumatology, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.

作者： Wei,Li ^[1] ; Yanlin,Zhong ^[1] ; Zhencan,Lin ^[1] ; Zengfa,Deng ^[2] ; Dianbo,Long ^[1] ; Ming,Li ^[1] ; Changzhao,Li ^[3] ; Guping,Mao ^[4] ; Yan,Kang ^[5]

作者单位： Department of Sports Medicine, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China; Guangdong Provincial Key Laboratory of Orthopedics and Traumatology, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China. ^[1] Department of Sports Medicine, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China; Guangdong Provincial Key Laboratory of Orthopedics and Traumatology, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China; Department of Sports Medicine and Joint Surgery, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China. ^[2] Department of Orthopaedics, General Hospital of Southern Theater Command, Guangzhou, China. Electronic address: changzhao.li@hotmail.com. ^[3] Department of Sports Medicine, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China; Guangdong Provincial Key Laboratory of Orthopedics and Traumatology, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China. Electronic address: maogp@mail2.sysu.edu.cn. ^[4] Department of Sports Medicine, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China; Guangdong Provincial Key Laboratory of Orthopedics and Traumatology, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China. Electronic address: kangyan2@mail.sysu.edu.cn. ^[5]

关键词 Forsythiaside A Nrf2 inflammasome mitophagy osteoarthritis senescence