De novo production of protoberberine and benzophenanthridine alkaloids through metabolic engineering of yeast.

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第一作者： Xiang,Jiao

第一单位： Department of Life Sciences, Chalmers University of Technology, Kemivägen 10, SE-412 96, Gothenburg, Sweden.

作者： Xiang,Jiao ^[1] ; Xiaozhi,Fu ^[1] ; Qishuang,Li ^[2] ; Junling,Bu ^[2] ; Xiuyu,Liu ^[2] ; Otto,Savolainen ^[3] ; Luqi,Huang ^[4] ; Juan,Guo ^[5] ; Jens,Nielsen ^[6] ; Yun,Chen ^[7]

作者单位： Department of Life Sciences, Chalmers University of Technology, Kemivägen 10, SE-412 96, Gothenburg, Sweden. ^[1] State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, 16 Neinanxiaojie, Dongcheng district, Beijing, China. ^[2] Department of Life Sciences, Chalmers University of Technology, Kemivägen 10, SE-412 96, Gothenburg, Sweden.;Chalmers Mass Spectrometry Infrastructure, Chalmers University of Technology, Kemivägen 10, SE-412 96, Gothenburg, Sweden. ^[3] State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, 16 Neinanxiaojie, Dongcheng district, Beijing, China. huangluqi01@126.com. ^[4] State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, 16 Neinanxiaojie, Dongcheng district, Beijing, China. guojuanzy@163.com. ^[5] Department of Life Sciences, Chalmers University of Technology, Kemivägen 10, SE-412 96, Gothenburg, Sweden. nielsenj@chalmers.se.;BioInnovation Institute, DK-2200, Copenhagen N, Denmark. nielsenj@chalmers.se. ^[6] Department of Life Sciences, Chalmers University of Technology, Kemivägen 10, SE-412 96, Gothenburg, Sweden. yunc@chalmers.se. ^[7]

主题词酿酒酵母菌(Saccharomyces cerevisiae);苯并菲啶类(Benzophenanthridines);小檗因生物碱类(Berberine Alkaloids);生物碱类(Alkaloids);小檗碱(Berberine)

DOI 10.1038/s41467-024-53045-3

PMID 39384562

发布时间 2024-10-11

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