Improving CYP2C19 phenotyping using stereoselective omeprazole and 5-hydroxy-omeprazole metabolic ratios.

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第一作者： Kenza,Abouir

第一单位： Division of Clinical Pharmacology and Toxicology, Geneva University Hospitals, Geneva, Switzerland.;School of Pharmaceutical Sciences; Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, Geneva, Switzerland.

作者： Kenza,Abouir ^[1] ; Emmanuel,Varesio ^[2] ; Julien,Déglon ^[3] ; Caroline,Samer ^[4] ; Youssef,Daali ^[4]

作者单位： Division of Clinical Pharmacology and Toxicology, Geneva University Hospitals, Geneva, Switzerland.;School of Pharmaceutical Sciences; Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, Geneva, Switzerland. ^[1] School of Pharmaceutical Sciences; Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, Geneva, Switzerland. ^[2] Division of Clinical Pharmacology and Toxicology, Geneva University Hospitals, Geneva, Switzerland.;Forensic Toxicology and Chemistry Unit, University Center of Legal Medicine Lausanne-Geneva, Lausanne University Hospital, Geneva University Hospital, Lausanne, Switzerland. ^[3] Division of Clinical Pharmacology and Toxicology, Geneva University Hospitals, Geneva, Switzerland.;School of Pharmaceutical Sciences; Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, Geneva, Switzerland.;Faculty of Medicine, University of Geneva, Geneva, Switzerland. ^[4]

关键词 5‐hydroxy‐omeprazole CYP2C19 enantiomers omeprazole phenotyping