Discovery of Novel 5-(Pyridazin-3-yl)pyrimidine-2,4(1<i>H</i>,3<i>H</i>)-dione Derivatives as Potent and Orally Bioavailable Inhibitors Targeting Ecto-5'-nucleotidase.-论文-万方医学网

第一作者： Yu,Xu

第一单位： Center of Drug Discovery, Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease, China Pharmaceutical University, Nanjing 210009, China.

作者： Yu,Xu ^[1] ; Dan,Liu ^[2] ; Wenzhuang,Zhang ^[1] ; Zhining,Liu ^[1] ; Jingjing,Liu ^[2] ; Wanling,Zhang ^[2] ; Rongxing,Song ^[2] ; Jia,Li ^[2] ; Fan,Yang ^[1] ; Yue,Wang ^[1] ; Dunkai,Liu ^[1] ; Gaofei,Qian ^[3] ; Hua,Tang ^[4] ; Xijing,Chen ^[2] ; Yisheng,Lai ^[1]

作者单位： Center of Drug Discovery, Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease, China Pharmaceutical University, Nanjing 210009, China. ^[1] Clinical Pharmacology Research Center, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 211198, China. ^[2] State Key Laboratory of Pharmaceutical Biotechnology, Department of Biochemistry, School of Life Sciences, Nanjing University, Nanjing 210023, China. ^[3] State Key Laboratory of Pharmaceutical Biotechnology, Department of Biochemistry, School of Life Sciences, Nanjing University, Nanjing 210023, China.;Engineering Research Center of Protein and Peptide Medicine, Ministry of Education, Nanjing 210023, China. ^[4]

主题词 5'-核苷酸酶(5'-Nucleotidase);动物(Animals);投药, 口服(Administration, Oral);人类(Humans);大鼠(Rats);小鼠(Mice);女(雌)性(Female);构效关系(Structure-Activity Relationship);抗肿瘤药(Antineoplastic Agents);细胞系, 肿瘤(Cell Line, Tumor);酶抑制剂(Enzyme Inhibitors);哒嗪类(Pyridazines);男(雄)性(Male);药物发现(Drug Discovery);小鼠, 近交BALB C(Mice, Inbred BALB C);大鼠, Sprague-Dawley(Rats, Sprague-Dawley);生物利用度(Biological Availability);微粒体, 肝(Microsomes, Liver);嘧啶类(Pyrimidines);嘧啶酮类(Pyrimidinones);GPI连接蛋白质类(GPI-Linked Proteins)

DOI 10.1021/acs.jmedchem.4c01793

PMID 39385716

发布时间 2024-10-24

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Discovery of Novel 5-(Pyridazin-3-yl)pyrimidine-2,4(1<i>H</i>,3<i>H</i>)-dione Derivatives as Potent and Orally Bioavailable Inhibitors Targeting Ecto-5'-nucleotidase.

Journal of medicinal chemistry

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Journal of medicinal chemistry

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Discovery of Novel 5-(Pyridazin-3-yl)pyrimidine-2,4(1<i>H</i>,3<i>H</i>)-dione Derivatives as Potent and Orally Bioavailable Inhibitors Targeting Ecto-5'-nucleotidase.

Journal of medicinal chemistry

相似文献

Journal of medicinal chemistry

相关期刊

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