Discovery of Ketal-Ester Ionizable Lipid Nanoparticle with Reduced Hepatotoxicity, Enhanced Spleen Tropism for mRNA Vaccine Delivery.

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作者： Kai,Lv ^[1] ; Zhenlei,Yu ^[2] ; Jing,Wang ^[1] ; Na,Li ^[2] ; Apeng,Wang ^[1] ; Tiezheng,Xue ^[1] ; Qixin,Wang ^[2] ; Yanqin,Shi ^[2] ; Lu,Han ^[2] ; Wei,Qin ^[2] ; Jiaqi,Gong ^[1] ; Huijuan,Song ^[1] ; Tingting,Zhang ^[2] ; Chunyan,Chang ^[2] ; Hua,Chen ^[2] ; Xijun,Zhong ^[1] ; Jian,Ding ^[2] ; Rui,Chen ^[2] ; Mingliang,Liu ^[1] ; Weiguo,Zhang ^[2] ; Shan,Cen ^[1] ; Yijie,Dong ^[2]

作者单位： Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China. ^[1] RinuaGene Biotechnology Co. Ltd, Suzhou, Jiangsu, China. ^[2]

关键词 biodegradability ionizable lipid mRNA delivery organ tropism toxicity

主题词动物(Animals);小鼠(Mice);纳米粒子(Nanoparticles);脂类(Lipids);脾(Spleen);疾病模型, 动物(Disease Models, Animal);癌症疫苗(Cancer Vaccines);女(雌)性(Female);小鼠, 近交C57BL(Mice, Inbred C57BL);肝(Liver);RNA, 信使(RNA, Messenger);脂质体(Liposomes)

DOI 10.1002/advs.202404684

PMID 39387241

发布时间 2024-12-07

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Advanced science (Weinheim, Baden-Wurttemberg, Germany)

2024年11卷45期

e2404684页

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Discovery of Ketal-Ester Ionizable Lipid Nanoparticle with Reduced Hepatotoxicity, Enhanced Spleen Tropism for mRNA Vaccine Delivery.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

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Advanced science (Weinheim, Baden-Wurttemberg, Germany)

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Discovery of Ketal-Ester Ionizable Lipid Nanoparticle with Reduced Hepatotoxicity, Enhanced Spleen Tropism for mRNA Vaccine Delivery.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

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Advanced science (Weinheim, Baden-Wurttemberg, Germany)

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