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BRCA1 levels and DNA-damage response are controlled by the competitive binding of circHIPK3 or FMRP to the BRCA1 mRNA.

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第一作者： Chiara,Grelloni

第一单位： Department of Biology and Biotechnology Charles Darwin, Sapienza University of Rome, 00185 Rome, Italy.

作者： Chiara,Grelloni ^[1] ; Raffaele,Garraffo ^[1] ; Adriano,Setti ^[1] ; Francesca,Rossi ^[1] ; Giovanna,Peruzzi ^[2] ; Mario,Cinquanta ^[3] ; Maria Carmela,Di Rosa ^[4] ; Marco Alessandro,Pierotti ^[3] ; Manuel,Beltran ^[5] ; Irene,Bozzoni ^[6]

作者单位： Department of Biology and Biotechnology Charles Darwin, Sapienza University of Rome, 00185 Rome, Italy. ^[1] Center for Life Nano- & Neuro-Science, Fondazione Istituto Italiano di Tecnologia (IIT), 00161 Rome, Italy. ^[2] Cogentech ltd Benefit C. Registered Office, 20133 Milan, Italy. ^[3] Local Unit c/o Scientific & Technologic Park of Sicily, 95121 Catania, Italy. ^[4] Department of Biology and Biotechnology Charles Darwin, Sapienza University of Rome, 00185 Rome, Italy. Electronic address: manuel.beltrannebot@uniroma1.it. ^[5] Department of Biology and Biotechnology Charles Darwin, Sapienza University of Rome, 00185 Rome, Italy; Center for Life Nano- & Neuro-Science, Fondazione Istituto Italiano di Tecnologia (IIT), 00161 Rome, Italy. Electronic address: irene.bozzoni@uniroma1.it. ^[6]

关键词 BRCA1 DNA-damage response FMRP RNA-RNA interaction anti-cancer treatments circRNAs translational regulation