BRCA promoter methylation in triple-negative breast cancer is preserved in xenograft models and represents a potential therapeutic marker for PARP inhibitors.
第一作者:
Kavitha,Däster
第一单位:
Breast Center Zurich, Zurich, Switzerland. Kavitha.daester@brust-zentrum.ch.;University of Basel, Basel, Switzerland. Kavitha.daester@brust-zentrum.ch.
作者:
医学主题词
人类(Humans);DNA甲基化(DNA Methylation);女(雌)性(Female);动物(Animals);启动区, 遗传(Promoter Regions, Genetic);异种移植模型抗肿瘤试验(Xenograft Model Antitumor Assays);小鼠(Mice);BRCA2蛋白质(BRCA2 Protein);BRCA1蛋白质(BRCA1 Protein);细胞系, 肿瘤(Cell Line, Tumor);中年人(Middle Aged);成年人(Adult);基因表达调控, 肿瘤(Gene Expression Regulation, Neoplastic)
DOI
10.1007/s10549-024-07502-8
PMID
39392573
发布时间
2025-04-25
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