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Model-directed generation of artificial CRISPR-Cas13a guide RNA sequences improves nucleic acid detection.

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第一作者： Sreekar,Mantena

第一单位： Broad Institute of MIT and Harvard, Cambridge, MA, USA.;Department of Statistics, Harvard University, Cambridge, MA, USA.;Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA, USA.

作者： Sreekar,Mantena ^[1] ; Priya P,Pillai ^[2] ; Brittany A,Petros ^[3] ; Nicole L,Welch ^[2] ; Cameron,Myhrvold ^[4] ; Pardis C,Sabeti ^[5] ; Hayden C,Metsky ^[6]

作者单位： Broad Institute of MIT and Harvard, Cambridge, MA, USA.;Department of Statistics, Harvard University, Cambridge, MA, USA.;Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA, USA. ^[1] Broad Institute of MIT and Harvard, Cambridge, MA, USA. ^[2] Broad Institute of MIT and Harvard, Cambridge, MA, USA.;Division of Health Sciences and Technology, Harvard Medical School and Massachusetts Institute of Technology, Cambridge, MA, USA.;MD-PhD Program, Harvard/Massachusetts Institute of Technology, Boston, MA, USA.;Department of Systems Biology, Harvard Medical School, Boston, MA, USA. ^[3] Department of Molecular Biology, Princeton University, Princeton, NJ, USA.;Department of Chemical and Biological Engineering, Princeton University, Princeton, NJ, USA.;Omenn-Darling Bioengineering Institute, Princeton University, Princeton, NJ, USA.;Department of Chemistry, Princeton University, Princeton, NJ, USA. ^[4] Broad Institute of MIT and Harvard, Cambridge, MA, USA. pardis@broadinstitute.org.;Howard Hughes Medical Institute, Chevy Chase, MD, USA. pardis@broadinstitute.org.;Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA, USA. pardis@broadinstitute.org.;Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, USA. pardis@broadinstitute.org. ^[5] Broad Institute of MIT and Harvard, Cambridge, MA, USA. hayden@broadinstitute.org. ^[6]

医学主题词算法(Algorithms);碱基序列(Base Sequence)

DOI 10.1038/s41587-024-02422-w

PMID 39394482

发布时间 2025-09-19

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