Targeting NAD+ Metabolism Vulnerability in FH-Deficient Hereditary Leiomyomatosis and Renal Cell Carcinoma with the Novel NAMPT Inhibitor OT-82.

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第一作者： Susana S,Najera

第一单位： Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland.;Chemical Biology Laboratory, National Cancer Institute, Frederick, Maryland.

作者： Susana S,Najera ^[1] ; Christopher J,Ricketts ^[2] ; Laura S,Schmidt ^[3] ; Julia I,Medina ^[2] ; Keita,Saito ^[4] ; Lilia,Ileva ^[4] ; Jeffrey R,Brender ^[5] ; Amy M,James ^[6] ; Cody J,Peer ^[7] ; Brad,Gouker ^[8] ; Baktiar O,Karim ^[8] ; Olga,Chernova ^[9] ; Catherine,Wells ^[2] ; Ming-Hui,Wei ^[2] ; Youfeng,Yang ^[2] ; Xiaohu,Zhang ^[10] ; Carleen,Klumpp-Thomas ^[10] ; Jameson,Travers ^[10] ; Lu,Chen ^[10] ; Kelli M,Wilson ^[10] ; Sameer H,Issaq ^[2] ; William D,Figg ^[7] ; Simone,Difilippantonio ^[6] ; Joseph D,Kalen ^[4] ; Murali C,Krishna ^[5] ; Craig J,Thomas ^[10] ; Michele,Ceribelli ^[10] ; Christine M,Heske ^[11] ; Daniel R,Crooks ^[2] ; Jordan L,Meier ^[12]

作者单位： Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland.;Chemical Biology Laboratory, National Cancer Institute, Frederick, Maryland. ^[1] Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland. ^[2] Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland.;Basic Science Program, Frederick National Laboratory for Cancer Research, Frederick, Maryland. ^[3] Small Animal Imaging Program, Frederick National Laboratory for Cancer Research, Frederick, Maryland. ^[4] Radiation Biology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland. ^[5] Animal Research Technical Support, Frederick National Laboratory for Cancer Research, Frederick, Maryland. ^[6] Genitourinary Malignancies Branch, National Cancer Institute, NIH, Bethesda, Maryland. ^[7] Molecular Histopathology Laboratory, Frederick National Laboratory for Cancer Research, Frederick, Maryland. ^[8] Oncotartis, Inc., Buffalo, New York. ^[9] Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland. ^[10] Pediatric Oncology Branch, National Cancer Institute, NIH, Bethesda, Maryland. ^[11] Chemical Biology Laboratory, National Cancer Institute, Frederick, Maryland. ^[12]