首页> Genome biology> HBI: a hierarchical Bayesian interaction model to estimate cell-type-specific methylation quantitative trait loci incorporating priors from cell-sorted bisulfite sequencing data.

HBI: a hierarchical Bayesian interaction model to estimate cell-type-specific methylation quantitative trait loci incorporating priors from cell-sorted bisulfite sequencing data.

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第一作者： Youshu,Cheng

第一单位： Department of Biostatistics, Yale School of Public Health, New Haven, CT, 06511, USA.;VA Connecticut Healthcare System, West Haven, CT, 06516, USA.

作者： Youshu,Cheng ^[1] ; Biao,Cai ^[2] ; Hongyu,Li ^[2] ; Xinyu,Zhang ^[3] ; Gypsyamber,D'Souza ^[4] ; Sadeep,Shrestha ^[5] ; Andrew,Edmonds ^[6] ; Jacquelyn,Meyers ^[7] ; Margaret,Fischl ^[8] ; Seble,Kassaye ^[9] ; Kathryn,Anastos ^[10] ; Mardge,Cohen ^[11] ; Bradley E,Aouizerat ^[12] ; Ke,Xu ^[13] ; Hongyu,Zhao ^[14]

作者单位： Department of Biostatistics, Yale School of Public Health, New Haven, CT, 06511, USA.;VA Connecticut Healthcare System, West Haven, CT, 06516, USA. ^[1] Department of Biostatistics, Yale School of Public Health, New Haven, CT, 06511, USA. ^[2] VA Connecticut Healthcare System, West Haven, CT, 06516, USA.;Department of Psychiatry, Yale School of Medicine, New Haven, CT, 06511, USA. ^[3] Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. ^[4] Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, 35294, USA. ^[5] The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. ^[6] Department of Psychiatry, SUNY Downstate Health Sciences University School of Medicine, Brooklyn, NY, USA. ^[7] Department of Medicine, University of Miami School of Medicine, Miami, FL, USA. ^[8] Division of Infectious Diseases and Tropical Medicine, Georgetown University, Washington, DC, USA. ^[9] Department of Medicine, Albert Einstein College of Medicine, New York, NY, USA. ^[10] Hektoen Institute for Medical Research, Chicago, IL, USA. ^[11] Bluestone Center for Clinical Research, College of Dentistry, New York University, New York, NY, USA.;Department of Oral and Maxillofacial Surgery, College of Dentistry, New York University, New York, NY, USA. ^[12] VA Connecticut Healthcare System, West Haven, CT, 06516, USA. ke.xu@yale.edu.;Department of Psychiatry, Yale School of Medicine, New Haven, CT, 06511, USA. ke.xu@yale.edu. ^[13] Department of Biostatistics, Yale School of Public Health, New Haven, CT, 06511, USA. hongyu.zhao@yale.edu.;VA Connecticut Healthcare System, West Haven, CT, 06516, USA. hongyu.zhao@yale.edu. ^[14]

关键词 Cell-sorted methylation sequencing data Cell-type-specific DNA methylation Colocalization Methylation quantitative trait loci hierarchical Bayesian interaction model

医学主题词数量性状基因座位(Quantitative Trait Loci);DNA甲基化(DNA Methylation);贝叶斯定理(Bayes Theorem);人类(Humans);序列分析, DNA(Sequence Analysis, DNA);模型, 遗传学(Models, Genetic)

DOI 10.1186/s13059-024-03411-7

PMID 39407252

发布时间 2026-02-11

基金项目

U01 HL146202/HL/NHLBI NIH HHS/United States U01 HL146204/HL/NHLBI NIH HHS/United States U01 HL146245/HL/NHLBI NIH HHS/United States UL1 TR001863/TR/NCATS NIH HHS/United States

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