Impact of Optimized Ku-DNA Binding Inhibitors on the Cellular and In Vivo DNA Damage Response.

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作者： Pamela L,Mendoza-Munoz ^[1] ; Narva Deshwar,Kushwaha ^[2] ; Dineshsinha,Chauhan ^[2] ; Karim Ben,Ali Gacem ^[3] ; Joy E,Garrett ^[4] ; Joseph R,Dynlacht ^[4] ; Jean-Baptiste,Charbonnier ^[5] ; Navnath S,Gavande ^[6] ; John J,Turchi ^[7]

作者单位： Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA. ^[1] Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI 48201, USA. ^[2] Institute for Integrative Biology of the Cell (I2BC), Institute Joliot, CEA, CNRS, Université Paris-Sud, 91198 Gif-sur-Yvette Cedex, France.;Structure-Design-Informatics, Sanofi R&D, 94400 Vitry sur Seine, France. ^[3] Department of Radiation Oncology, Indiana University School of Medicine, Indianapolis, IN 46202, USA. ^[4] Institute for Integrative Biology of the Cell (I2BC), Institute Joliot, CEA, CNRS, Université Paris-Sud, 91198 Gif-sur-Yvette Cedex, France. ^[5] Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI 48201, USA.;Molecular Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit, MI 48201, USA. ^[6] Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.;NERx Biosciences, Indianapolis, IN 46202, USA. ^[7]

关键词 DNA-PK Ku-DBis double-strand break repair non-homologous end joining non-small cell lung cancer small-molecule inhibitors

DOI 10.3390/cancers16193286

PMID 39409907

发布时间 2024-10-19

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